By Stephen J. (editor) Lippard
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Additional resources for Platinum, Gold, and Other Metal Chemotherapeutic Agents. Chemistry and Biochemistry
Sample text
Showed that both compounds can produce SCE, thus SCE producTion can be d i s s o c i a t e d from mutagenicity (16). ; ACS Symposium Series; American Chemical Society: Washington, DC, 1983. 42 METAL CHEMOTHERAPEUTIC AGENTS Table I I . 19 18 Source: a b <10~ 5 1303 2300 880 1200 522 Reference 3. S u r v i v a l of colony-forming a b i l i t y . HGPRT l o c u s . ; ACS Symposium Series; American Chemical Society: Washington, DC, 1983. 40 99 79 116 106 2. ch002 ~ι Crosslinks 43 Γ 4 3x10" m 2x10" Ξ ce 4 I 1x10- οί ο JL _L 5 100 200 15 μΜ c/s-DDP 10 300 400 500 600 μΜ trans-DDP DRUG CONCENTRATION Figure 10.
W. "Cisplatin. Current Status and New Developments"; Prestayko, A. ; Crooke, S. ; Carter S. K. ; Academic Press: New York, 1980; pp. 21-35. ; ACS Symposium Series; American Chemical Society: Washington, DC, 1983. 3 Structural Chemistry of P l a t i n u m - D N A Adducts THOMAS D. TULLIUS, H. MICHAEL USHAY, CAROLYN M. MERKEL, JOHN P. CARADONNA, and STEPHEN J. ch003 Columbia University, Department of Chemistry, New York, NY 10027 Aspects of the binding of the antitumor drug, cis-diamminedichloroplatinum(II) (cis-DDP), and other platinum complexes to DNA are reviewed.
Proteolytic enzymes can be used to distinguish DPC from ISC. DPC form rapidly and are the major lesion produced by trans-DDP. ISC form over 6-12 hr following treatment and are more efficiently formed by cis-DDP. ISC correlated more closely with cytotoxicity than did DPC. This was confirmed using chemical blockade of ISC formation to enhance cell survival following cis-DDP treatment. Additionally, malignant cells resistant to cis-DDP in vitro and in vivo showed lower levels of ISC than their sensitive parent lines.
