By Herbert A Kirst, Wu-Kuang Yeh
Eli Lily and corporate, Greenfield, identification. Reference offering an updated overview of enzyme services in human and animal health and wellbeing, together with assurance of recent and rising applied sciences in biotechnical and pharmaceutical industries. Emphasizes glossy tools of metabolic engineering and drug discovery approaches, and info enzymes concerning human illness.
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Extra resources for Enzyme Technologies for Pharmaceutical and Biotechnological Applications
Sample text
E2-Sp2-A2 ϩ E3-Sp3-Val → E3-Sp3-Val-A2 ϩ E2-Sp2H (12) Ep3 TE E3-Sp3-Val-A2 → E3-Sp3-D-Val-A2 → A2-D-Val ϩ E3-Sp3H (13) Likewise, the assumed O-methyl-serinyl-thioester intermediate reacts only slowly with the Aad thioester, but is readily released by aminolysis of free Val [reaction (14), with A2 either Cys or O-methyl-serine] or may react with the Val-thioester intermediate to be further processed [reactions (12) and (13), with O-methyl-serine for A2]. E2-Sp2-A2 ϩ Val → E2-Sp2H ϩ A2-Val (14) Following the dipeptide synthesis from O-methyl-serine and Val by determining the loss 18O from di[18O]valine, evidence for both reactions was obtained, but a direct reaction of Cys-AMP with free Val cannot be excluded [reaction (15)].
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The structure of a peptide, containing alpha-aminoadipic acid, cysteine and valine, present in the mycelium of Penicillium chrysogenum. Biochem J 76:357–361, 1960. 15. K Bauer. Zur Biosynthese der Penicilline: bildung von 5-(2-aminoadipyl)cysteinyl-valin in extrakten von penicillium chrysogenum. Z Naturforsch [B] 25: 1125–1129, 1970. 16. PB Loder, EP Abraham. Biosynthesis of peptides containing alpha-aminoadipic acid and cysteine in extracts of a Cephalosporium sp. Biochem J 123:477–482, 1971. 17.
