By Leonard Gomella, Steven Haist, Aimee Adams
Must-know information regarding one thousand of the main time-honored medictions -- at your fingertips and able to use! compliment for a prior version: "This is a truly priceless and up to date pocket reference for prevalent medicinal drugs. five Stars!"--Doody's overview carrier Why spend time plowing via info you don't want whilst what you really want to understand is correct the following in a single concise advisor? sufficiently small to slot in a lab coat or blouse pocket, Clinician's Pocket Drug Reference is simply what you must perform more secure and quicker medication. prepared alphabetically by means of conventional drug identify universal makes use of, mechanisms of motion, dosages (adult and pediatric), precautions/contraindications, shape provided, and notes/common uncomfortable side effects features a record of the drugs equipped via drug category Summaries of the FDA “black field” precautions and contraindications up to date to incorporate assurance of greater than 24 new medicines and the removing of substances taken off the industry
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Extra info for Clinician's Pocket Drug Reference 2009
CI in PRG; ✓ monthly PRG tests Uses: *Pulmonary arterial HTN* Action: Endothelin receptor antagonist Dose: Adults. 5 mg PO/d, max 10 mg/d; not ok w/ hepatic impair Caution: [X, –] w/ Cyclosporine, strong CYP3A or 2C19 inhibitor, inducers of P-glycoprotein, CYPs and UGTs CI: PRG Disp: Tabs 5, 10 mg SE: Edema, nasal congestion, sinusitis, dyspnea, flushing, constipation, HA, palpitations, hepatotoxic Notes: Available only through the Letairis Education and Access Program (LEAP); D/C AST/ALT >5× ULN or bilirubin >2× ULN or S/Sx of liver dysfunction; childbearing females must use 2 methods of contraception Amifostine (Ethyol) Uses: *Xerostomia prophylaxis during RT (head, neck, etc) where parotid is in radiation field; ↓ renal tox w/ repeated cisplatin* Action: Prodrug, dephosphorylated by alkaline phosphatase to active thiol metabolite; binds cisplatin metabolites Dose: 910 mg/m2/d 15-min IV Inf 30 min Aminoglutethimide 39 prechemotherapy Caution: [C, +/–] CV Dz Disp: 500-mg vials powder, reconstitute in NS SE: Transient ↓ BP (>60%), N/V, flushing w/ hot or cold chills, dizziness, ↓ Ca2+, somnolence, sneezing Notes: Does not ↓ effectiveness of cyclophosphamide + cisplatin chemotherapy Amikacin (Amikin) Uses: *Serious gram(–) bacterial Infxns* & mycobacteria Action: Aminoglycoside; ↓ protein synth Spectrum: Good gram(–) bacterial coverage: Pseudomonas & Mycobacterium sp Dose: Adults & Peds.
PO: Initial 100 mg/d; usual 300 mg/d; max 800 mg/d; ÷ dose if >300 mg/d IV: 200–400 mg/m2/d (max 600 mg/24 h); (after meal w/ plenty of fluid). Peds. Only for hyperuricemia of malignancy if <10 y: 10 mg/kg/24 h PO or 200 mg/m2/d IV ÷ q6–8h; max 600 mg/24 h; ↓ in renal impair Caution: [C, M] Disp: Tabs 100, 300 mg; Inj 500 mg/30 mL (Aloprim) SE: Rash, N/V, renal impair, angioedema Notes: Aggravates acute gout; begin after acute attack resolves; IV dose of 6 mg/mL final conc as single daily Inf or ÷ 6-, 8-, or 12-h intervals Almotriptan (Axert) Uses: *Rx acute migraine* Action: Vascular serotonin receptor agonist Dose: Adults.
Disp: Soln, inhaled and oral 10%, 20%; Acetadote IV soln 20% SE: Bronchospasm (inhaled), N/V, drowsiness, anaphylactoid Rxns w/ IV Notes: Activated charcoal adsorbs PO acetylcysteine for APAP ingestion; start Rx for APAP OD w/in 6–8 h Acitretin (Soriatane) WARNING: Must not be used by females who are pregnant or who intend to become pregnant during or for 3 y following D/C of therapy; EtOH must not be ingested during or for 2 mo following cessation; do not donate blood for 3 y following cessation; Hepatotoxic Uses: *Severe psoriasis*; 32 Acyclovir other keratinization disorders (lichen planus, etc) Action: Retinoid-like activity Dose: 25–50 mg/d PO, w/ main meal; ↑ if no response by 4 wk to 75 mg/d Caution: [X, –] Renal/hepatic impair; in women of reproductive potential CI: See Warning; ↑ serum lipids; w/ MTX or tetracyclines Disp: Caps 10, 25 mg SE: Hyperesthesia, cheilitis, skin peeling, alopecia, pruritus, rash, arthralgia, GI upset, photosensitivity, thrombocytosis, hypertriglyceridemia, ↑ Na, K, PO4– Notes: Follow LFTs, lytes, lipids; response takes up to 2–3 mo; informed consent prior to use; FDA guide w/ each Rx Acyclovir (Zovirax) Uses: *Herpes simplex(HSV)(genital/mucocutaneous, encephalitis, keratitis), Varicella zoster, Herpes zoster (shingles) Infxns* Action: Interferes w/ viral DNA synth Dose: Adults.