By J. B. Smith (auth.), P. V. Halushka, D. E. Mais (eds.)
The unique sequence, Advances in Prostaglandin learn, edited by way of Sultan M. M. Karim, was once released by way of MTP Press in 3 volumes in 1975 and 1976. a look at these books illustrates the growth that has been made for the reason that then. The thromboxanes have been pointed out two times (first e-book 1975) and prostacyclin now not as soon as (first ebook 1976); leukotrienes have been basically at the horizon. the fantastic iteration of analysis information within the final 10-15 years has given new, extensive insights into many components, together with bronchial asthma, irritation, renaL cardiovascular and gastrointestinal ailments and in replica, and has led in a few circumstances to genuine medical gain. This sequence, Advances in Eicosanoid learn, displays the present realizing of prostaglandins, thromboxanes and leukotrienes. the purpose is to supply an introductory history to every subject and the main up to date info to be had. even though each one e-book stands by myself, the eicosanoids lower throughout many barriers of their easy activities; chosen chapters from every one e-book within the sequence will offer illuminating and effective details for all readers with a purpose to improve their schooling and examine. within the construction of this sequence, i need to recognize with excitement my collaboration with editors and authors and the sufferer endeavours of Dr Michael Brewis and the employees at MTP Press.
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Additional info for Eicosanoids in the Cardiovascular and Renal Systems
Sample text
Lear and V. E. Kelley INTRODUCTION Arachidonic acid (AA) metabolites are produced by a variety of renal cells, although the eicosanoid profile varies among different cell types and regions of the kidney. The details of eicosanoid biosynthesis and metabolism are discussed in a preceding chapter. The importance of arachidonic acid metabolites in renal disease has emerged from experimental studies and clinical evaluation of immunologically mediated, as well as non-immune, forms of renal injury. Since arachidonic acid metabolites (eicosanoids), in particular thromboxane (TxA z), prostacyclin (PGI z), prostaglandin Ez (PGE z) and leukotrienes (LT), can regulate haemodynamic and immunological/inflammatory events, an alteration in the metabolism of any of these molecules can promote or protect the formation of renal injury.
These metabolites promote water excretion, are natriuretic, stimulate renin release, and modulate renal haemodynamics, both by increasing overall renal blood flow (RBF) and by preferentially increasing blood flow to the inner cortical and medullary regions. In addition, the action of PG is inextricably intertwined with the actions of other hormones and factors on the kidney. Although it is well established that cyclo-oxygenase derivatives of AA are involved in renal pathophysiological states, products of non-cyclo-oxygenase pathways may play a pathogenetic role in human renal disease which is as yet to be elucidated.
Renal cytochrome P450-related arachidonate metabolite inhibits (Na + -K +)A TPase. Nature (London), 314, 620-622 32. J. and Orloff, J. (1968). Effect of prostaglandin E] on the permeability response of the isolated collecting tubule to vasopressin, adenosine 3', 5'-monophosphate, and theophylline. ]. Clin. , 47, 1154-1161 31 EICOSANOIDS IN THE CARDIOVASCULAR AND RENAL SYSTEMS 33. E. L. (1981). Kinin-induced prostaglandin synthesis by renal papillary collecting tubule cells in culture. Am. ]. , 241, F94-FI04 34.
