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Dyspnea : mechanisms, measurement, and management by Donald A. Mahler

By Donald A. Mahler

"With the excessive occurrence of persistent pulmonary ailments, reminiscent of bronchial asthma, COPD, and interstitial lung ailment, it is very important comprehend the mechanisms, size, and administration of dyspnea, that is the patient́'s basic grievance. Physicians have to realize the reason for dyspnea and understand how to regard it, making sure that sufferers can cope successfully with this distressing symptom. Dyspnea: Mechanisms, Read more...


Preceded by means of Dyspnea / edited by way of Donald A. Mahler, Denis E. O'Donnell. 2d ed. 2005. Read more...

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LeDoux JE. Emotion circuits in the brain. Annu Rev Neurosci. 2000;23:155–84. Phan KL, Wager TD, Taylor SF, et al. Functional neuroimaging studies of human emotions. CNS Spectr. 2004;9(4):258–66. Paulus MP, Stein MB. An insular view of anxiety. Biol Psychiatry. 2006;60(4):383–7. Lang PJ, Davis M. Emotion, motivation, and the brain: Reflex foundations in animal and human research. Prog Brain Res. 2006;156:3–29. Watanabe J, Sugiura M, Sato K, et al. The human prefrontal and parietal association cortices are involved in NO-GO performances: An event-related fMRI study.

51–54 These studies indicate that the perception of mechanical loading is consistently reduced in the elderly, whereas the sensation of respiratory muscle force production is not different compared with younger subjects during resting breathing. 55 evaluated the effects of progressive hypercapnia with and without inspiratory flow-resistive loading on dyspnea intensity. These authors showed that dyspnea intensity ratings were higher in older subjects aged 61–79 years compared with younger subjects aged 19–48 years at end-tidal CO2 values of 45, 50, 30 Dyspnea: Mechanisms, Measurement, and Management and 55 mmHg, irrespective of the presence or absence of inspiratory flow-resistive loading.

Liotti M, Brannan S, Egan G, et al. Brain responses associated with consciousness of breathlessness (air hunger). Proc Natl Acad Sci U S A. 2001;98(4):2035–40. Denton D. The Primordial Emotions: The Dawning of Consciousness. New York: Oxford University Press; 2005. Julius SM, Davenport KL, Davenport PW. Perception of intrinsic and extrinsic respiratory loads in c­hildren with life-threatening asthma. Pediatr Pulmonol. 2002; 34(6):425–33. Nguyen BP, Wilson SR, German DF. Patients’ perceptions compared with objective ratings of asthma severity.

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