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Cumulative Subject Index by Saul L. Neidleman and Allen I. Laskin (Eds.)

By Saul L. Neidleman and Allen I. Laskin (Eds.)

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Rnyxogenes gum, production and properties, 23:34 Azotobacter vinelandii alginic acid production by, 23:28-29 hydrogen production technology and, 38~247-248 Azotobacter xylinurn sucrose phosphorylase activity, 32166 AZT, see Zidovudine B Bacillomycin L, 24:199 Bacillus a-amylase production and, 35:7, 8, 10-12 enzyme characteristics, 35:40, 41 recovery, 35:39 yields, 35:35, 36 growth, 35:34, 35 incubation, 35:33 industrial production, 35:14, 15, 17 moisture, 3529 pH, 35:30 present status, 35:18-21, 24 research needs, 35:43-45 B.

40:143-145 examples, 40:145-148 process systems approach, 40:99-107 overview, 40:95-96 product development, 40:156-173 constraints, 40:156-159 delivery concepts, 40:162-164 examples, 40:166-173 environmental services, 4 0 3 72-1 73 insulin discovery and development, 40:169-172 from penicillin to new class of antibiotics, 40:166-169 microbial route development, 40:165-166 product formulation, 40:162-164 resource statistics, 40:159-162 25 funnel diagram, 40:160-161 inverted triangle concept, 40:161-162 pipeline concept, 40:159-160 strategies, 40156-159 discovery, 40115-141 approaches, 40:131-140 classification, 40:115-120 versus manufacturing routes, 40:121-125 new chemical class discovery, 40: 125-1 2 7 other industrial sector products, 40:128-131 plant product discovery, 40:127-128 screens, 40:115-121 serendipity, 40:140 top 20 drugs, 40:140-141 regulation of genetically engineered microorganisms, 402 74-280 crop improvement plants, 34282-289 tissue culture, 34281 embryo transfer, 34297, 300 energy, 34277, 280 enzymes, 34276-279 foodborne yeasts and, 36:180 gibberellins and, 34:llO human protein, 34:289, 290 growth hormone, 34:291 insulin, 34:291 interferon, 34991 interleukin-2, 34:292 recombinant DNA, 34293 renin, 34:292 tissue plasminogen activator, 34291, 292 industrial organism, 34264-269 inherited diseases, 34296-299 microbial enzyme use in, 25:18-22 monoclonal antibodies, 34:294, 295 pollutants, 34:275 processes, environment and, 36:67-68, 82 case studies, 36:75-76 agriculture, 36:79-80 chemical bioprocesses, 36:78-79 food bioprocesses, 36:76-77 mining, 36:79 26 CUMULATIVE SUBJECT INDEX Biotechnology (continued) pharmaceutical bioprocesses, 36:77-78 waste treatment, 36:78 ecology, 36:69 dispersion, 36:69-70 genetic exchange, 36:71-73 survival, 36:70 hazards, 36:68-69 motivation, 3669 regulation, 3680-82 risk assessment, 3673-74 human, 36:74-76 protein analysis and, 36:323-324 technology protein chemistry, 34274, 275 recombinant DNA, 34:269-271 reverse genetics, 34271-274 vaccines, 34292, 294 Biotin antibody technologies and, 38:162, 190 antimetabolites, 22163 actithiazic acid, 22164-166 adenine, 22:169-170 amiclenomycin, 22168-169 a-dehydrobiotin, 22:166-167 a-methylbiotin, 22167-168 a-methyldethiobiotin, 22167-168 stravidin, 22:16&169 bacterial gene transfer in soil and, 35:95, 146, 147, 149, 151 biosynthetic pathways to, 22146-148 biotin synthesizing reaction, 22:147, 153-155 dethiobiotin synthetase, 22:147, 151-153 7,8-diaminopelargonic acid, 22147, 149-151 7-keto-8-aminopelargonic acid, 22147, 149 pimilyl-CoA synthetase, 22148 chemical synthesis of, 22158-159 microbial degradation of,22170-172 microbial synthesis of, 22160-161 protein analysis and, 36294 regulation of biotin synthesis, 2 2 3 55-1 57 uses of, 22:146 Biotransformation environmental, 40:289-300 dicamba, 40291-295 other chlorinated and nonchlorinated compounds, 40:295-300 by immobilized plant cells, 2814-22 process discovery, 40:143-145 sterol, 39:62-63 Biotyping, 33:48, 49 Biparental mating, recombinant E.

Peucetius mutants, 32209-210 production by S. 82 foodborne yeasts and, 36231-232 genetically engineered microorganisms and, 38:36 herbicides and pesticides and, 3636, 42 CUMULATIVE SUBJECT INDEX pBR322, 36:92, 97, 99 phenotypes with, genetically engineered microorganisms and, 38:32-35 recombinant E. coli K-12 and, 36105, 109,115,116-117,120,121 selection, 36:97-98 water, 36:102-103 Antibiotics 33-25, 24201-202 AB-1, 24:203 A-3302-B, 24~212 a-amylase production and, 35:lO anoxygenic phototrophic bacteria and, 38280 antibody technologies and, 38195 autotoxic, tolerance to, in producer organisms, 25:152-162 bacterial gene transfer in soil and, 35:62, 64 conjugation, 35:75, 77, 79, 80, 83 study methods, 35:122-125, 128 environmental factors, 35:67, 70 recombinants, 35:140-142 transduction, 35:102, 137, 138 biotechnology and, 34264, 280, 281 BU 1880,24:203 chorismate-derived production of, 25:75-93 common subunits of, 27:59 culture resistance to, 25:76-81 development of, 33:327 EM-49,24199-202 enzyme inactivation of, 25:78-80 extraction procedure, 33:326-330 feedback control of, 25:162-164 Ganoderrna, 37:102, 123 genetically engineered microorganisms and, 38:69, 91 gibberellins and, 3488, 101 product development, 40:166-169 secondary metabolism and, 34:5, 7-9, 12 similar subunit structures in, 28:33 substances from bacteria, 41:202-203 from fungi and ascomycetes, 34242, 243 basidiomycetes, 34238, 240, 241 fungi imperfecti, 34230-232, 234, 236 11 history, 34:184 phycomycetes, 34244 production, 34186-206 screening, 34:185 target-site modification by, 25:152-157 TL-119, 2 4 2 11-2 1 2 TM-743, 24~203 tolerance to by excretion-exclusion, 25:157-162 in producer organisms, 25:147-168 V-8495, 24~203 xenobiotics and, 35917 xenotoxic, 25:149-152 Antibodies anoxygenic phototrophic bacteria and, 38251 biotechnology and, 34:290, 292, 294 cellular cytotoxicity dependence on, antibody technologies and, 38:171, 175, 181 Ganoderrna, 37:118-119 hydrodynamic shear stress, 37201 labeling, hydrodynamic shear stress, 37:189 levan and, 35:180, 190 microbial cytochromes P450 and, 36:146, 151, 163 protein analysis and, 36291, 294, 316, 318, 323 Antibody technologies affinity chromatography, 38:160-161 enzyme immunoassay, 38:187-191 future, 38:194-195 high-performance liquid chromatography, 38:158-159 history, 38:150-15 1 immunofluorescence, 38:186-187 immunoglobulin-binding proteins, 38~157-158 immunotherapy, 38:180 cancer, 38:181-182 immunoglobulin fragments, 38:180-181 immunotoxins, 38:182-183, 185 Pseudomonas exotoxin, 38:184-185 ricin, 38:183-184 monoclonal antibodies, 38161-162 bispecificity, 38166-167 catalytic antibodies, 38167-170 fusion, 38:162 12 CUMULATIVE SUBJECT INDEX Antibody technologies (continued) hybridomas, 38163-164 nonmurine, 38164-165 specificity, 38:165-166 polyclonal antibodies adjuvants , 3 8153-1 55 delivery, 38:155 idiotypes, 38:155-157 lipid-derivatized antibodies, 38:155 synthetic peptides, 38:151-153 precipitation, 38:158 radiolabels, 38:186 recombinant antibodies eukaryotes, 38:171-172 heterochimeras, 38:174-175 homochimeras, 38:175-177 libraries, 38:172-174 mutagenesis, 38:174 prokaryotes, 38170-1 71 single chain, 38:177-179 size, 38:179-180 recombinant DNA affinity purification, 38:192 epitope mapping, 38:192-194 immunoscreening, 38:191-192 transplactation, 38181 Antiflammatory activity, Gonoderrno, 37:119-120 Antifoams adverse effects of, 33:189-191 carriers, 33:185, 189 characteristics, desired, 33:187-188 chemical, for fermentations, 33:181-184 combined with other defoaming methods, 33:211-213 definition of, 33:180 foam breakage mechanisms of, 33:185-186 oxygen transfer rate and, 33:191-192 selection criteria, 33:186-189 type and nature of, 33:180-185 Antifungal agents, from streptomycetes, tolerance to, in producer organisms, 25:152 Antigens antibody technologies and, 38:150, 187, 192,194 enzyme immunoassay, 38:187-189, 191 immunotherapy, 38:180-182 monoclonal antibodies, 38:162, 164-167,169-170 polyclonal antibodies, 38:151-156 recent developments, 38:160 recombinant antibodies, 38:174-177, 17S180 bacterial gene transfer in soil and, 35:151 biotechnological processes and, 36:77 biotechnology and, 34:290, 292, 294, 295 foodborne yeasts and, 36:180 Ganoderma, 37:118 levan and, 35:180, 190 microbial cytochromes P450 and, 36:163 protein analysis and, 36:291, 316, 323 recombinant E.

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