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BarCharts QuickStudy Pharmacology by Becky Rodda, Suzanne L., Ph.D. Tinsley

By Becky Rodda, Suzanne L., Ph.D. Tinsley

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1996) examined N-methyl-R-salsolinol (IR,2-dimethyl-6, 7-dihydroxy-l ,2,3,4tetrahydroisoquinoline) and salsolinol for their neurotoxicity for dopaminergic neurons by stereotaxic injections into the left corpus striatum of male Wistar rats. 100 nmol of the compounds dissolved in Ringer solution were injected into the rat striatum at a flow rate of 1 ",,112 min (total volume 5 ",,1). Only N-methyl-R-salsolinol induced behavioral changes very similar to those found in Parkinson's disease, including hypokinesia; stiff tail, limb twitching, and postural abnormalities.

Neurosci. Lett. 91:349-353. , and Ikebe S. (1994) An immunohistochemical study on a-ketoglutarate dehydrogenase complex in Parkinson's disease. Ann. Neurol. 35:204-210. , and Kompf D. (1992) Presence of methy 1-6,7-dihydroxy-l ,2,3,4-tetrahydroisoquinolines, derivatives of the neurotoxin isoquinoline, in parkinsonian lumbar CSF. Life Sci. 50:1885-1891. , and Bamberg H. (1995) Presence of N-methyl-norsalsolinol in the CSF: correlations with dopamine metabolites of patients with Parkinson's disease.

1980) Neuroamine condensations in human subjects. Adv. Exp. Med. BioI. 126:87-102. , and Origitano TC. (1983) Catecholamine-derived tetrahydroisoquinolines: O-methylation patterns and regional brain distribution following intraventricular administration in rats. 1. Neurochem. 41:1569-1575. , and Naoi M. (1995) Determination of the (R)- and (S)-enantiomers of salsolinol and N-methylsalsolinol by use of a chiral high-performance liquid chromatographic column. 1. Chromatogr. 670: 47-54. , and Vernay D.

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