By Walter A. Korfmacher
The 1st variation of this now vintage paintings helped to set up mass spectrometry because the ideal device for drug metabolism reports. thoroughly rewritten from begin to end, utilizing Mass Spectrometry for Drug Metabolism reviews, moment version brings medicinal chemists and mass spectrometry pros on top of things with the swift advances within the box, the emergence of state-of-the-art techniques, and how you can meet gradually expanding seller calls for. Written by way of overseas scientists who're specialists of their respective disciplines, this cutting-edge reference successfully encapsulates present mass spectrometry most sensible practices. The stand-alone chapters hide a number of subject matters – from metabolite identity to quickly chromatography with UPLC – and in a method that's comprehensible to specialists and box newbies alike. the second one version of this bestseller comprises insurance of latest instrumentation and software program in addition to a wealth of up to date details at the most recent findings surrounding biomarkers and metabolomics and new chapters on either UPLC and DESI/DART. With greater than one hundred eighty illustrations and an eight-page colour insert, this necessary reference explores a number of glossy mass spectrometry innovations and methods. It contains an outstanding evaluate of the complete drug discovery strategy plus the most recent advancements on how mass spectrometry is used to help this exercise.
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Extra info for Using Mass Spectrometry for Drug Metabolism Studies, Second Edition
Sample text
Removal of metabolite interference during liquid chromatography/ tandem mass spectrometry using high-field asymmetric waveform ion mobility spectrometry, Rapid Commun. , 19(14), 1979, 2005. 97. , High-field asymmetric waveform ion mobility spectrometry coupled with liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-FAIMS-MS/MS) multi-component bioanalytical method development, performance evaluation and demonstration of the constancy of the compensation voltage with change of mobile phase composition or flow rate, Rapid Commun.
72. T. , Elimination of autosampler carryover in a bioanalytical HPLC-MS/ MS method: A case study, J. Pharm. Biomed. , 36(5), 1073, 2005. 73. Zeng, W. , A new approach for evaluating carryover and its influence on quantitation in high-performance liquid chromatography and tandem mass spectrometry assay, Rapid Commun. , 20(4), 635, 2006. 74. , A novel approach for in-process monitoring and managing cross-contamination in a high-throughput high-performance liquid chromatography assay with tandem mass spectrometric detection, Rapid Commun.
48. Jemal, M. , Enhanced resolution triple-quadrupole mass spectrometry for fast quantitative bioanalysis using liquid chromatography/tandem mass spectrometry: Investigations of parameters that affect ruggedness, Rapid Commun. , 17(1), 24, 2003. 49. Pucci, V. , Enhanced mass resolution method development, validation and assay application to support preclinical studies of a new drug candidate, Rapid Commun. , 20(8), 1240, 2006. 50. T. , Mass Spectrometry in Drug Discovery. 2002, Marcel Dekker, Inc: New York.
