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Toxicological profiles - Vinyl Chloride by Syracuse Research Corporation

By Syracuse Research Corporation

The ATSDR toxicological profile succinctly signify the toxicological and opposed healthiness results details for the unsafe substance defined therein. the point of interest of the profiles is on health and wellbeing toxicological details; accordingly each one toxicological profile starts off with a public future health assertion that describes, in nontechnical language, a substance's suitable toxicological houses.

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Extra resources for Toxicological profiles - Vinyl Chloride

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Chronic exposure of rats to 5,000 ppm vinyl chloride 7 hours per day, 5 days per week, for 1 year resulted in increases in areas of myodegeneration in the heart and thickening of the walls of arteries (Feron and Kroes 1979). However, the statistical significance of this effect was not reported. Exposure of rats to 30,000 ppm of vinyl chloride for 4 hours per day, 5 days per week, for 1 year also produced thickening of the walls of small arterial vessels. The thickening was characterized by a proliferation of the endothelium.

1984). Brief exposure of animals to extremely high concentrations of vinyl chloride has been shown to cause hepatic damage. For example, acute exposure (30 minutes) of guinea pigs and mice to 300,000 ppm of vinyl chloride caused liver congestion or severe fatty degeneration while 200,000 ppm caused fatty infiltration in rats (Mastromatteo et al. 1960). -ketoglutarate transaminase activity in rats (Jaeger et al. 1974). However, exposure of rats to 50,000 ppm for 6 hours produced no observable effects on the liver (Reynolds et al.

1983 5 F (CEL: mammary gland carcinoma) Maltoni et al. 1981 TABLE 2-1. Levels of Significant Exposure to Vinyl Chloride - Inhalation (continued) LOAEL (effect) a Key to figure a Species/ (strain) Exposure duration/ frequency 70 Mouse (CD-1) 1-12 mo 5d/wk 6hr/d 71 Hamster (Golden Syrian) 12, 18, 24 mo 5d/wk 6hr/d System NOAEL (ppm) Less serious (ppm) Serious (ppm) 50 B (CEL: hepatic hemangiosarcoma; bronchiolo-alveolar adenoma; malignant lymphoma) 50 F (CEL: mammary gland adenoma and adenocarcinoma) 200 F (CEL: liver hemangiosarcoma; skin carcinoma, hemangiosarcoma; spleen hemangiosarcoma; mammary gland carcinoma; stomach adenoma) Reference Lee et al.

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