By S. Webb
The Physics of Conformal Radiotherapy: Advances in know-how offers an intensive evaluate of conformal radiotherapy and organic modeling, targeting the underlying physics and technique of three-d ideas in radiation treatment. This rigorously written, authoritative account evaluates 3-dimensional therapy making plans, optimization, photon multileaf collimation, proton remedy, transit dosimetry, intensity-modulation options, and organic modeling. it truly is a useful instructing consultant and reference for all clinical physicists and radiation oncologists/therapists that use conformal radiotherapy.
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Extra resources for The physics of conformal radiotherapy : advances in technology
Example text
I) maximise TCP subject to some maximum-allowed NTCP; (ii) minimise NTCP subject to some minimum-allowed TCP; (iii) maximise the probability of uncomplicated ttlmour control TCPx - NTCP). Note, however, that a physical parameter cannot both be a constraint and a goal for optimisation simultaneously. Not all these objectives are endorsed. For example option (iii) might correspond to a too high NTCP. Clinicians usually set an upper bound to the NTCP as a constraint and (i) is often the preferred clinical rationale in determining a treatment.
1 -4) The change A C ( n ) in the cost function between iterations n and ( n - 1) is then A C ( n ) = C ( n ) - C ( n - 1). (1 3) If A C ( n ) < 0 the change in the driving variables is always accepted. If A C ( n ) > 0 the change is accepted with a probability where the denominator kbT(n) has the same dimensions as A C ( n ) and is itself a function of n. The variable T ( n ) may be thought of as a temperature if kb is the Boltzmann constant and A C ( n ) has units of energy. So called ‘classical’ simulated annealing iteration proceeds by starting with a large temperature (high probability of accepting ‘uphill’ changes leading to A C ( n ) > 0) and decreases the temperature slower than (1/ log(n)) so gradually reducing this probability to zero.
What is treatment-plan optimisation? The aim of radiotherapy of local disease is to achieve a high dose to the planning target volume, simultaneously keeping the dose to OAR as low as possible. When it is intended to use a small number of rectangular fields with or without wedges and blocking, the treatment-planning technique is to try a number of different beam weightings, compute the dose distribution, evaluate the plan and then repeat the task until satisfied that the plan meets prescribed criteria.
