By Robert A. Turner
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Additional resources for Screening Methods in Pharmacology
Example text
A pair of electrodes is attached to the preganglionic part of the nerve. This preparation is chiefly intended to measure ganglionic activity, with the nictitating membrane as the organ exhibiting responses. The activity may be determined by means of a lever that writes on a kymograph and is attached by thread, passing over a system of pulleys, to the nictitating membrane. Usually the blood pressure of the carotid artery is measured simultaneously. When the nerve is stimulated electrically, the membrane contracts, as long as the current is maintained.
When the unaffected mouse is placed in the supine position on the back of the observer's hand, held in a fist so that the thumb can support the mouse's head, it tries to escape (4). The unaffected mouse tries to escape when held vertically by one forepaw (6), or by one hind paw (8). Passivity in any of these positions is scored as given. Intermediate scores are used when the struggle is diminished but not abolished (Fig. 3). 2. Mood The unaffected mouse grooms itself frequently. Its grooming (4) may be excessive and indicate central stimulation or sympathetic III.
Is there salivation? Is the size of the pupil affected? Is tremor present? Is the palpebrai aperture affected? Are the ears different in color? Is there lacrimation? Is there excessive excretion? Is the urine normal in appearance? V. TESTS OTHER THAN NEUROPHARMACOLOGICAL Following the neuropharmacological observations on mice, the usual practice is to perform some tests with isolated organs, with organs in situ, and with intact animals. The choice of these tests and their sequence must depend on the investigator and his predilections.
