By F. Lechin, B. van der Dijs, M.E. Lechin
The authors of this ebook built the single scientific neurochemistry laboratory built usually to assay all circulating neurotransmitters. those parameters were measured in additional than 20,000 common, seriously diseased, depressed, under pressure and psychosomatic sufferers. the consequences received were released in additional than a hundred clinical papers. The authors postulated the lifestyles of no less than 3 well-defined forms of pathophysiologic profiles: endogenous melancholy, dysthymic melancholy, and uncoping (maladapted) to emphasize. Being conscious of them, clinicians can prescribe targeted neuropharmacological treatments. the 1st and 3rd profiles also are registered in Th1 and Th2 autoimmune diseased sufferers, respectively. the 1st a part of the booklet is dedicated to the description of those relevant neurocircuitry services through the wake-sleep cycle in basic matters in addition to depressive states, uncoping tension, psychotics, bipolar issues and panic assaults.
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Extra info for Neurocircuitry and Neuroautonomic Disorders: Reviews and Therapeutic Strategies
Sample text
However, indirect evidence supports the inference that whereas NA (A6) overactivity + 5HT (B7-B8) inhibition underlie endogenous depression, the opposite profile of NA (A6) hypoactivity + 5HT (B7-B8) hyperactivity would exist in dysthymic depression. Our hypothesis receives additional support from the finding that whereas sleep deprivation induces maladaptation to stress syndrome, the same procedure is able to improve depression [Vogel, 1975]. Conclusions Evidence is presented showing the existence of three distinct syndromes in humans: (1) endogenous depression; (2) dysthymic depression, and (3) maladaptation to stress.
2. m. 5 Ìg/kg) and placebo on norepinephrine plasma level, systolic and diastolic blood pressure in 26 high distal colon tone depressed patients. Systolic blood pressure was significantly reduced at 30, 60, 90 and 120 min. Neither diastolic blood pressure nor norepinephrine plasma levels were reduced at any period. , Neuroendocrinology 1985b;41:156– 162]. one neuropharmacological mechanism and act upon more than one neurotransmitter system. , 1991]. Amineptine inhibits the uptake of DA [Sherman and Petty, 1980].
Finally, in 1995 we published other two papers (Biological Psychiatry) demonstrating that the two reported types of depressed patients fit well with the diagnoses of endogenous (major), and dysthymic depressed patients. The neurochemical, neurophysiological and neuropharmacological profile of dysthymic depressed patients will be defined and depicted in this chapter. The dysthymic depression diagram is characterized by smaller than normal blue disk (NA system) plus a big DRserotonergic system (yellow disk).
