By Robert D. Timmerman MD, Lei Xing PhD
This e-book offers particular, state of the art info and directions at the newest advancements, strategies, and medical strategies in image-guided and adaptive radiation remedy. the 1st part discusses key methodological and technological concerns in image-guided and adaptive radiation remedy, together with use of implanted fiducial markers, administration of breathing movement, image-guided stereotactic radiosurgery and stereotactic physique radiation treatment, three-d conformal brachytherapy, objective definition and localization, and PET/CT and biologically conformal radiation treatment. the second one part presents functional scientific info on image-guided adaptive radiation treatment for cancers in any respect universal anatomic websites and for pediatric cancers. The 3rd part bargains sensible guidance for constructing an efficient image-guided adaptive radiation treatment program.
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Additional info for Image-Guided and Adaptive Radiation Therapy
Solutions and local optima. Clinically, the need for robust deformable registration algorithms to fuse images acquired under different conditions or with different modalities is ever increasing because of the extensive use of multimodality imaging and the emergence of new imaging methods. 12,62–65 Two central issues in deformable registration are ( a) definition of the registration metric function and ( b) algorithm to find the transformation that optimizes the metric function. A metric function is usually constructed based on some physical considerations and used to measure the goodness of an arbitrary association of the two images.
Med Phys. 2007;34:4041–4063. C H AP T E R 2 Lei Xing Louis Lee Robert Timmerman I mage-gu id ed Ad aptive Rad iation T h erapy an d P ractical Perspectives With the development of intensity-modulated radiation therapy ( IMRT) in the 1990s, radiation therapy ( RT) entered a new era. By optimally modulating the incident beam fluences, exquisite dose distribution can be planned and delivered. 1–5 In reality, however, a highly conformal dose distribution is not enough; the dose should also be delivered to the right place at the right time.
Clinically, the need for robust deformable registration algorithms to fuse images acquired under different conditions or with different modalities is ever increasing because of the extensive use of multimodality imaging and the emergence of new imaging methods. 12,62–65 Two central issues in deformable registration are ( a) definition of the registration metric function and ( b) algorithm to find the transformation that optimizes the metric function. A metric function is usually constructed based on some physical considerations and used to measure the goodness of an arbitrary association of the two images.