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Dermatomyositis: Advances in Recognition, Understanding and by Lyubomir A. Dourmishev MD, PhD, Assen L. Dourmishev MD, PhD,

By Lyubomir A. Dourmishev MD, PhD, Assen L. Dourmishev MD, PhD, DSc (auth.)

Although dermatomyositis is a unprecedented connective tissue disorder, many physicians are faced with the analysis and remedy of sufferers suffering from this situation. according to the gigantic own adventure of the authors, who've clinically determined, taken care of, and controlled many dermatomyositis sufferers, this medical consultant offers dermatologists, rheumatologists, pediatricians, neurologists, and basic practitioners with the keys to reading the scientific indicators of dermatomyositis. additionally incorporated are algorithms to assist the reader to make the proper analysis, in addition to suggestions on new diagnostic tools and therapy schemes.

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An association has also been found of the overproducing TNF alpha-308A variant with adult DM and with subacute cutaneous LE [57]. The significantly increased incidence of specific genes that correlate with overproduction or decreased clearance of apototic cells, along with HLA genes involved with antigen presentation, supports the concept of the relationship between genetic and environmental influences that trigger cutaneous autoimmune disease [83]. 7 Seasons and Climate The role of the environment in the evolution of DM, whether in regard to climate or geographic location, has not been fully identified and may vary by years and locations.

Dermatomyositis presenting as erythroderma. J Am Acad Dermatol 1992; 26: 489–490. 81. Pierson JC, Taylor JS. Erythrodermic dermatomyositis. J Am Acad Dermatol 1993; 28: 136. 82. Maruani A, Armingaud P, Nseir A, et al. Erythroderma and cutaneous necrosis in patient with dermatomyositis. Ann Dermatol Venereol 2003; 150: 353–356. 83. Glover M, Leigh I. Dermatomyositis pemphigoides: a case with coexistent dermatomyositis and bullous pemphigoid. J Am Acad Dermatol 1992; 27: 849–852. 84. Barrows-Wade L, Jordon RE, Axnett FC.

Gardner-Medwin JM, Dolezalova P, Cummins C, et al. Incidence of Henoch-Schönlein purpura, Kawasaki disease, and rare vasculitides in children of different ethnic origins. Lancet 2002; 360: 1197–1202. 26. Pachman LM, Hayford JR, Chung A, et al. Juvenile dermatomyositis at diagnosis: clinical characteristics of 79 children. J Rheumatol 1998; 25(6): 1198–1204. 27. Peloro TM, Miller OF, Hahn TF, et al. Juvenile dermatomyositis: a retrospective review of a 30-year experience. J Am Acad Dermatol 2001; 45: 28–34.

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