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Clinical management of chronic obstructive pulmonary disease by Thomas Similowski, William Whitelaw, Jean-Philippe Derenne

By Thomas Similowski, William Whitelaw, Jean-Philippe Derenne

This reference offers a entire evaluate of the newest recommendations used to evaluate, deal with, and deal with sufferers in each one section of persistent obstructive pulmonary disorder (COPD)-offering the newest diagnostic modalities to spot and distinguish elements of COPD in prior, extra reversible stages.

Contains views from the area future health association at the epidemiology and keep watch over of COPD in Africa, South the US, and jap Europe!

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Extra resources for Clinical management of chronic obstructive pulmonary disease

Sample text

Those exposed to dust or fumes in their work should be counseled to change jobs, something often easier said than done. Symptomatic therapy. Bronchodilator drugs are the major element of symptomatic therapy. These drugs have generally been studied in COPD after they have been shown to be effective in asthma. The apparent superiority of inhaled ipratropium bromide in COPD as compared with beta-agonists may be a result of the doses used for comparison. Studies have shown that there is no further bronchodilation when either ipratropium or a beta agonist is given after maximal bronchodilation produced with the other agent.

The administration of a bronchodilator does not influence the fall in lung function, consistent with the idea that airway inflammation and not simply the presence of bronchoconstriction is responsible for the effect. Why is it 4 Cosio et al. then that airway responsiveness is a risk for accelerated deterioration in lung function in smokers? Generally methacholine responsiveness is interpreted as reflecting the reaction of airway smooth muscle to so-called nonspecific constrictive agonists. This may not be a correct assumption.

A baseline is provided for measuring progress of the disease. Improvement of Ͼ25% of the FEV1 suggests that a patient may have asthma or the asthmatic form of COPD. The FEV1 may also be used to stage COPD into mild, moderate, and severe. Staging gives guidance for the use of arterial blood gas measurements. These are not indicated for mild disease. Pulse oxymetry should be done on patients with moderate disease. If saturation at rest and during mild exercise is 88% or less, a resting arterial blood gas measurement with the patient breathing air should be done to provide baseline value of PCO2 and to confirm the oxygen level.

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