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Chiral separations by liquid chromatography and related by Hassan Y. Aboul-Enein

By Hassan Y. Aboul-Enein

Unique in its systematic and particular description of many of the forms, buildings, and houses of chiral desk bound stages (CSPs) and their coaching, software, and destiny scope, this quantity highlights an collection of liquid chromatographic methods, together with sub- and super-critical fluid chromatography, capillary electrochromatography, and skinny layer chromatography. Readers will locate: plausible optimization thoughts for enantiomeric answer on numerous sorts of CSPs and new concepts in liquid chromatography and comparable applied sciences of chiral separations. it's a worthy source full of 1200 of the latest and suitable literature citations.

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The chiral recognition capacities of cellulose tribenzoate (CTB) derivatives was explored by Okamoto et al. [8,17]. The effect of the substituents on the phenyl ring of cellulose tribenzoate (Chiralcel OB) has also been systematically studied [17]. Alkyl, halogen, trifluoromethyl, and methoxy groups were selected as the substituents. Resolution ability was greatly affected by the inductive effect of such substituents. Benzoate derivatives having electron-donating substituents such as methyl groups showed better chiral recognition ability than those having electron-withdrawing substituents, such as halogens.

32. 33. 34. 35. 36. 37. 38. 39. 40. 41. 42. 43. 44. 45. 46. Arie¨ns EJ, Trends Pharmacol Sci 200 (1986). Waldeck B, Chirality 5: 355 (1993). Simonyi M, Fitos I, Visy J, Trends Pharmacol Sci 112 (1986). Cannon JG, Moe ST, Long JP, Chirality 3: 19 (1991). Krstulovic AM, Chiral Separations by HPLC: Applications to Pharmaceutical Compounds, Ellis Horwood, New York (1989). , Ellis Horwood, New York (1991). ), A Practical Approach to Chiral Separations by Liquid Chromatography, VCH Verlag, Weinheim, Germany (1994).

FIGURE 10 Chromatograms of enantiomeric resolution on cellulose tribenzoate CSPs. 2 mM benzoic acid. 2 mM phenol. (c) Ic aromatase inhibitor on Chiralcel OJ-R CSP, with acetonitrile– water (50 : 50, v=v) as the mobile phase. (d) IIc aromatase inhibitor on Chiralcel OJ-R CSP, with acetonitrile–water (50 : 50, v=v) as the mobile phase. For structures of Ic and IIc aromatase inhibitors, see later (Fig. 18). (From Refs. ) Copyright 2003 by Marcel Dekker, Inc. All Rights Reserved. tuents, such as methoxy and nitro groups, show poor chiral recognition [18].

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