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Bioengineering Approaches to Pulmonary Physiology and by Michael C. K. Khoo (auth.)

By Michael C. K. Khoo (auth.)

As the present millennium steams in the direction of a detailed, one can't support yet glance with amazement on the superb volume of growth that has been accomplished in medication in precisely the previous couple of a long time. A key contributing issue to this luck has been the importation and mixing of rules and strategies from disciplines outdoors the normal borders of scientific technological know-how. lately, the main famous instance is the cross-pollination among molecular biology and medication. Advances pushed by way of this powerful mixture have spawned the imaginative and prescient of a destiny the place remedies according to gene remedy develop into general. but, as we proceed our look for "magic bullets" within the quest to remove disorder, it very important to acknowledge the worth of different less-heralded interdisciplinary efforts that experience laid a wide a part of the basis of present-day medication. In pulmonary medication, the contribution from the bioengineers (a various selection of contributors cross-bred to numerous levels in mathematical modeling and experimental body structure) has been greater and extra sustained than in lots of different clinical specialties. you can element to the significant array of ventilators, blood-gas analyzers, oximeters, pulmonary functionality units, and breathing displays which are found in any glossy scientific atmosphere as sturdy proof of the profitable synergy among engineering technology and pulmonary drugs. despite the fact that, one must never overlook the fewer tangible, yet probably extra very important, contributions which have been derived from mathematical modeling and desktop simulation, with no which lots of those sleek tools do not have come into existence.

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15 1 but any value can be selected. 8 and cardiac output at 5 1/min. Pulmonary shunt is defaulted at 2% 31 The North Carolina Respiratory Model so 60 70 &D 90 100 110 IZO - OXYGEN PBESSWaB-mmlfiJ MODEL c _o a I. D V) C o o> >. X o 20 40 60 80 100 120 140 Oxygen Pressure, mm Hg Figure 8. Oxyhemoglobin dissociation curves at different pH/PCO, values. Top: for human blood from Dill''*. Bottom: from model using calculated P50 values and Hill's equation. Only below 40% SaO, do the model's curves differ much from the Dill curves.

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