By David R. Gross D.V.M., Ph.D. (auth.)
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Additional info for Animal Models in Cardiovascular Research
Example text
American Association for Laboratory Animal Science, Manual for Laboratory Animal Technicians. Publication 67-3, Dec. 1, 1979, Section II: page 140. 2. , Temperature Regulation and Env ironmental Physiology in Duke's Physiology of Domestic Animals. , ed. J. Swenson, Cornell Univ. Press, Ithaca, NY, p. 687, 1977. 3. , Cholinerg ic Pharmacology: Autonomic Drugs, in veterinary Pharmacology and Therapeutics. ,ed. H. E. McDonald, The Iowa State University Press, Ames, Iowa, 1982. 4. , Anesthesia of bulls undergoing surgical manipulation of the vas deferentia.
12mg/kg , IV Intact, awake, instrumented, adult, pain free Recommended dosage for preanesthesia No change in umbilical blood flow or fetal 02 consumption during 120 min observation period. Transient maternal hyperglycemia. Umbilical vein glucose levels were significantly decreased and fetal glucose uptake was markedly decreased. 2: IV IV IV Large renal vascular dilation characterized by a 22% decrease in resistance and an 18% increase in flow. There was an increase in heart rate, a decrease in mean aortic pressure, an increase in cardiac output initially and then a significant decrease.
When the calcium ion concentration of the preparation was increased the Pentazocine induced decrease in contractility was antagonized. 03 mg/kg Conscious, previously instrumented. Drug applied to 4th cerebral ventricle Anesthetized with pentobarbital (3Omg/ kg, IV), acute, open chest preparation 50 microg/kg IV Dose 50 microg/kg IV intact of Fentanyl Anesthetized with ether then an electrolytic decerebration. The ether was then removed for more than 2 1/2 hrs. 5: Dose dependent increase in left ventricular dP/dt max and decrease in myocardial oxygen consumption, decreased pressure time index, decreased coronary sinus blood flow and heart rate Pronounced bradycardia, blood pressure and the blood pressure response to baroreflex activation not affected by this perturbation Mean aortic pressure decreased from l13±S to 72±10 mmHg and heart rate decreased from l55±14 to l14±15 beats/min Heart rate decreased from lll±ll to 42±3 beats/ min, respiratory rate went from 3S±5 to 9±2 Cardiovascular effects 47 55 54 54 Reference (J1 o 57 First a decrease then, after 7 min, an increase in precapillary pressure.
