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The Rhesus Factor And Disease Prevention (Wellcome Witnesses by Doris Teichler Zallen, D. A. Christie, E. M. Tansey

By Doris Teichler Zallen, D. A. Christie, E. M. Tansey (Editors)

The Wellcome belief Centre for the heritage of medication at UCL produces a variety of guides, together with the Wellcome Witnesses to 20th Century drugs sequence. those volumes are edited transcripts of Witness Seminars at which major figures in twentieth-century medication speak about discoveries and occasions in fresh clinical heritage. Twenty-two released volumes can be found from December 2004. For additional info see: www.ucl.ac.uk/histmed/witnesses.html The prevention of rhesus illness of the child stands as a beautiful clinical luck tale. This affliction bothered millions of newborns every year, inflicting critical illnesses, even loss of life. but from the early Forties to the Nineteen Seventies British and American researchers exposed the root of the affliction and built the scientific intervention which may hinder its prevalence. some of the key steps resulting in this awesome fulfillment happened on the collage of Liverpool college of medication. Chaired through Professor Sir David Weatherall this Witness Seminar, 'The Rhesus issue and ailment prevention' (volume 22), examines the criteria that caused those experiences and the demanding situations confronting scientists and clinicians; the highbrow, institutional, and social elements that guided the paintings; the an important insights; and the vistas that the prevention of Rh sickness has opened in fetal medication. members comprise Professor Robin Coombs, the past due Professor Ronald Finn, Dr Nevin Hughes-Jones, Professor Patrick Mollison, Dr Archie Norman, Dr Derrick Tovey, Professor Charles Whitfield, Professor John Woodrow and Professor Doris Zallen.

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24 See note 4. The Rhesus Factor and Disease Prevention they had actually a Rh-negative panel of 79 donors at that stage. At that time, of course, we knew nothing about exchange transfusion, but we were regularly treating babies who were diagnosed as having haemolytic disease, and we were treating them just with straight blood transfusions. 25 Weatherall: Thank you very much indeed. Just a matter of technology: was intramedullary transfusion, that is transfusion straight into the bone marrow, a standard practice for neonates at that time?

The kind of serendipity of timing is always so important and the ability to identify fetal cells in the maternal circulation is very important here. 80 Was it his group who first actually showed the value of it for detecting fetal cells in the maternal circulation? Finn: Yes. It was about 1956 or 1957, and I started in 1958, so we were very, very fortunate. As you were saying before, whatever the theory says, you have got to have the right technology, and it came along for us just at the right time.

33 There was only one’s sixth sense and a friendly radiologist who might want to get involved and take X-rays after injection of contrast media into the amniotic cavity. It had quite a high mortality rate, partly because it was reserved only for the sickest babies. Despite that, it spread around the world. I believe the first transfusion in this country was done by Mrs Jadwiga Karnicki at Lewisham. As soon as she heard of Liley’s success, she whizzed off to New Zealand, and it was a case of ‘see one, do one, teach one’, I think.

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