By Carsten Nieder, Johannes Langendijk
New advancements similar to subtle mixed modality techniques and critical technical advances in radiation therapy making plans and supply are facilitating the re-irradiation of formerly uncovered volumes. for that reason, either palliative and healing techniques should be pursued at a variety of illness websites. Re-irradiation: New Frontiers is the 1st e-book to supply a finished assessment on present re-irradiation recommendations. Re-irradiation equipment, technical features, the function of mixed treatment with anticancer medicines and hyperthermia, and general tissue tolerance are all mentioned intimately. additionally, disease-specific chapters record fresh scientific effects and destiny examine instructions. execs eager about radiation remedy making plans and multimodal oncology remedy will locate this publication to be a useful reduction in figuring out the advantages and obstacles of re-irradiation and in designing potential trials.
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Additional info for Re-irradiation: New Frontiers
Example text
A total of 108 patients with superficially located tumors with different origins was analyzed in detail. The patients received either radiation alone (n = 52) or radiation combined with LHT (n = 56). Of the patients who received radiation alone, 63% (33/52) had breast cancer or chest wall recurrences after a history of breast cancer, 12% (6/52) had head and neck cancer, 12% (6/52) had malignant melanoma, and 13% (7/52) had other tumor histologies. In the combined group the distribution was 66% (37/ 56), 14% (8/56), 9% (5/56), and 11% (6/56), respectively.
All these preconditions have to be considered for an individualized treatment schedule of a locally relapsed tumor. In case of previous irradiation doses of C50 Gy many radiation oncologists prefer to prescribe a palliative dose of another 30 Gy to a non-resectable local recurrence of rectal cancer to avoid serious side effects especially to the bladder and small intestine. It is well-known that a pathologically confirmed complete resection of the local recurrence of a rectal cancer opens a curative perspective for up to 50% of the patients (Dresen et al.
Radiother Oncol 88:388–397 Spencer SA, Harris J, Wheeler RH et al (2008) Final report of RTOG 9610, a multi-institutional trial of reirradiation and chemotherapy for unresectable recurrent squamous cell carcinoma of the head and neck. Head Neck 30:281–288 Stewart FA (1999) Re-treatment after full-course radiotherapy: is it a viable option? Acta Oncol 38:855–862 26 Stewart FA, Soranson JA, Alpen EL et al (1984) Radiationinduced renal damage: the effects of hyperfractionation. Radiat Res 98:407–420 Tomé WA, Howard SP (2007) On the possible increase in local tumour control probability for gliomas exhibiting low dose hyper-radiosensitivity using a pulsed schedule.
