By M. Frier, A C Perkins
This article defines the function and scope of nuclear medication imaging concepts (gamma scintigraphy) in pharmaceutical learn, giving details from scientific trial information.
Read or Download Nuclear Medicine in Pharmaceutical Research (TAYLOR & FRANCIS SERIES IN PHARMACEUTICAL SCIENCES) PDF
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Additional resources for Nuclear Medicine in Pharmaceutical Research (TAYLOR & FRANCIS SERIES IN PHARMACEUTICAL SCIENCES)
Sample text
1996) and reference should also be made to Chapter 4, which describes in detail the technical aspects and outcomes. Preparation procedures are, however, generally more complex than for the tablet study just described, and numerous GMP issues are raised. In the example chosen, metered dose inhalers containing 100 µg per actuation of a solid drug dispersed in a CFC propellant, were radiolabelled with Tc-99m pertechnetate to assess the effectiveness of a spacing device. Introduction of the radiolabel requires opening of the canister, and addition of pertechnetate, followed by resealing of the canister.
If accepted within the selected energy window the detected pulses are registered and positioned on the image at the appropriate X,Y coordinates. The image is built up over a period of time until sufficient counts are collected. The high voltage electrical supply and associated electronics are usually situated in a cabinet in close proximity to the head. Data collection is set and controlled by an acquisition module with TV monitor and keyboard. 6 Image Acquisition Scintigraphic images may be collected for a set number of counts or a set period of time.
3 Protocols It is essential that starting materials and finished products are clearly specified in protocols, which also include criteria for release of the finished product. Processing instructions need to be in writing, and provision made for recording of batch manufacturing details. However, it is recognized that the product specifications and processing instructions may vary during the developmental stages, and this is quite acceptable providing the rationale is explained, and any changes are authorized and recorded.
