By Alan Soo-Beng Khoo, Kin-Choo Pua (auth.), Pierre Busson MD, PhD (eds.)
This quantity intends to give a contribution to “translational drugs and biology”. by means of this, we suggest a bi-directional approach whose target is to advance wisdom from simple technology in the direction of diagnostic and healing purposes and reciprocally to elevate new questions for uncomplicated scientists. One common requirement for translational examine is to set up a multidisciplinary wisdom base shared by means of the actors of assorted specialties. this is often exactly the objective of the 12 chapters of this ebook. will probably be important for scientists, together with PhD scholars, who are looking to develop into extra acquainted with the most suggestions of NPC pathology, scientific imaging and present therapeutics. Conversely, doctors who are looking to replace their wisdom of NPC biology will take advantage of chapters on viral and mobile oncogenesis and numerous elements of host-tumor interactions.
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Extra resources for Nasopharyngeal Carcinoma: Keys for Translational Medicine and Biology
Example text
If the 2005 classification is adhered to then this distinction will be HISTOPATHOLOGICAL DIAGNOSIS OF NASOPHARYNGEAL CARCINOMA A 19 B Figure 2. Nonkeratinizing differentiated carcinoma. This tumour characteristically has well delineated nests of tumour cells, often with surface spread. The tumour cells at the periphery of the nests appear palisaded (A). In-situ hybridization for EBER demonstrates that all the tumour cells contain positive signal in the nucleus (B). lost and future prospective studies will have difficulty in determining prognosis related to histology.
Nonkeratinizing Carcinoma Nonkeratinizing carcinoma of the nasopharynx (WHO Category II), was microscopically identified as a tumour which is neither anaplastic or undifferentiated nor keratinizing. By description, this tumour produced neoplastic epithelium that was “transitional” in type. It often resembled transitional cell carcinoma of the urinary bladder. Cytologically, the cells were of moderate size, variable between polygonal and spindled and variable in differentiation. Nonkeratinizing carcinomas that were poorly differentiated often had the appearance of the tumour described by Regaud.
Even so, he as well as other pathologists of the time found difficulty in separating the transitional cell carcinoma from lymphoepithelioma. Even though Cappell thought that the lymphoepithelioma was more common than the transitional cell carcinoma he considered that there was great interobserver error. The place for transitional cell carcinoma in the 1940s still remained unclear—several workers claimed that it was inseparable from lymphoepithelioma whilst others saw it as a squamous cell carcinoma of low grade differentiation.
