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Evolving Approaches to Improve Outcomes and Minimize by G.M. Thomas

By G.M. Thomas

Even supposing experimental and medical melanoma learn have to be heavily associated, advances on the simple point usually stay distant from clinical software. This magazine works to speed up the interpretation of experimental effects to the hospital. In every one factor, findings from uncomplicated examine are built-in with present theoretical wisdom and mentioned by way of their relevance to the detection and remedy of melanoma. major medical experiences from melanoma centres all over the world are incorporated, supplemented through occasional case reviews and reports. This name examines evolving methods to enhance results and reduce toxicities in radiation remedy.

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Additional info for Evolving Approaches to Improve Outcomes and Minimize Toxicities in Radiation Therapy (Oncology)

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J Clin Oncol 1997;15:2996–3018.

In addition, this study is designed to evaluate whether this regimen can improve locoregional control rates, distant control, and/or survival. Vascular Endothelial Growth Factor (VEGF) Blockade VEGF is thought to play an important role in tumor angiogenesis. Blockade of its function is, therefore, considered a treatment target for a number of tumor types, and is likely to be tested in conjunction with combined modality therapy. Sugen (SU) 5416 SU 5416 is a small molecule that exhibits potent inhibition of the fetal liver kinase (flk) receptor tyrosine kinase, which is the receptor for VEGF.

A similar result was seen in a Japanese study reported by Furuse et al. [29]. These results support the positioning of concurrent chemoradiotherapy as the current standard of care. Although the ability to obtain positive results with consistency across studies is encouraging, it is important to note Oncology 2002;63(suppl 2):29–38 35 Table 1. Summary of some recently completed and ongoing major chemoradiation trials Study Treatment evaluated Completed phase III RTOG studies 9001 Concurrent chemoradiation for locally advanced cervical cancer 9410 Sequential vs concurrent chemoradiotherapy for stage III NSCLC 9003 Hyperfractionated and accelerated fractionated RT vs standard RT for locally advanced head and neck cancer 9202, 8610 Long- vs short-term adjuvant hormone therapy for locally advanced prostate cancer 8531 Adjuvant hormone therapy plus RT for localized prostate cancer 9111 Sequential or concurrent chemoradiotherapy vs RT alone for operable laryngeal cancer Phase III studies with completed accrual 9305, 9508 Radiosurgery for glioma and brain metastases 9501 Chemotherapy for resected head and neck cancer 9408 Androgen ablation for localized prostate cancer 9413 Large-field RT for advanced prostate cancer 9802 Chemotherapy for low-grade glioma Unreported/active phase III trials for stage III NSCLC (RTOG and other groups) RTOG 9801 Amifostine as radioprotectant ECOG 2597 Role of 3 times daily RT CALGB 39801 Evaluation of induction chemotherapy R 9309/Intergroup Role of surgery in N2 disease ECOG Role of thalidomide SWOG/Intergroup Role of EGFR blockade CALGB = Cancer and Leukemia Group B; ECOG = Eastern Cooperative Oncology Group; EGFR = Epidermal growth factor receptor; N2 = mediastinal lymph node metastasis; NSCLC = non-small-cell lung cancer; RT = radiotherapy; RTOG = Radiation Therapy Oncology Group; SWOG = Southwest Oncology Group.

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