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When the Air Hits Your Brain: Tales from Neurosurgery by Frank Vertosick Jr.

By Frank Vertosick Jr.

"Dramatic, relocating, and totally fascinating." —New York occasions publication Review
With poignant perception and humor, When the Air Hits Your Brain chronicles one man’s evolution from naïve and impressive younger intern to world-class neurosurgeon. In electrifying element, Frank Vertosick Jr. describes a few of the maximum demanding situations of his occupation, together with a six-week-old little one with a tumor in her mind, a tender guy struck down in his top via paraplegia, and a minister with a .22-caliber bullet lodged in his cranium. advised via intimate pictures of Vertosick’s sufferers and unsparing but fascinatingly exact descriptions of surgical systems, When the Air Hits Your Brain—the fruits of many years spent suffering to profit an unforgiving craft—illuminates either the mysteries of the brain and the realities of the working room.

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Scand J Gastroenterol 2001; 36:897–903. 50. Thun MJ, Namboodiri MM, Calle EE, Flanders WD, Heath CW, Jr. Aspirin use and risk of fatal cancer. Cancer Res 1993; 53:1322–1327. 51. Funkhouser EM, Sharp GB. Aspirin and reduced risk of oesophageal adenocarcinoma. Cancer 1995; 76:1116–1119. 52. Farrow DC, Vaughan TL, Hansten PD, Stanford JL, Risch HA, Gammon MD. Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev 1998; 2:97–102.

Cancer Res 2000; 60:5767–5772. 71. Sharma VK, Crowell MD, Howden CW. Infection with H. pylori or CAGA+ H. pylori is protective against Barrett’s oesophagus (BE): and esophageal adenocarcinoma (EAC): A meta-analysis. Gastroenterology 2004; 126(suppl 2): A-87 [Abstract 452]. 72. Lanas AI, Ortega J, Sopena F. Long-term effects of COX-2 inhibitor on oesophageal epithelial proliferation of patients with Barrett’s esophagus: Preliminary results of a randomized controlled trial. Gastroenterol 2004; 126(suppl 2):A-25.

Most research into the role of COX-2 inhibition in carcinogenesis has concentrated on animal studies and human colonic cancers. The hypothesis for COX-2 inhibition as a preventative strategy for esophageal adenocarcinoma originated from supportive evidence for its role in colonic cancer (31,32). The implication is that the studies and mechanisms discussed in this chapter may be transferable in our understanding of esophageal carcinoma. Indeed, COX-2 inhibition has been shown to reduce the development of esophageal adenocarcinoma in animal models (33).

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