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Toxicological profiles - Chlorophenols by Unknown

By Unknown

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Extra resources for Toxicological profiles - Chlorophenols

Sample text

Subjects were traced through the National Health Service Central Register and National Insurance Index and their mortality compared with that in the national population. Levels of exposure to phenoxy compounds, chlorophenols, or dioxins were not well characterized. A slightly elevated standardized mortality ratio (SMR) of 123 for cancer of the lung was reported. However, this may have been attributable to subtle differences in smoking behavior. 87. No other observed tumor incidence, including soft tissue sarcomas, was significantly elevated over the expected rates (Coggon et al.

1991; Ott et al. 1987). 8. No studies were located regarding death in humans following inhalation exposure to any of the chlorophenols discussed in this profile. CHLOROPHENOLS 2. HEALTH EFFECTS Nose-only exposure of male and female Wistar rats to 2-CP for 4 hours to a concentration of 908 ppm (Duchosal and Biederman 1991) and whole-body exposure of Sprague-Dawley rats to 2-CP for 6 hours at 620 ppm (Younger Labs 1975) did not result in any deaths. These studies are limited by a lack of experimental detail.

1961), 2,4,6-TCP (Bercz et al. 1990; Blackburn et al. 1986; NCI 1979), or 2,3,4,6-TeCP (American Biogenics 1988). Cardiovascular Effects. No studies were located regarding cardiovascular effects in humans after oral exposure to any of the eight chlorophenols discussed in this profile. CHLOROPHENOLS 2. HEALTH EFFECTS No change in heart weight was noted in mice fed 2,4-DCP at doses up to 230 mg/kg/day for 6 months (Kobayashi et al. 1972). Histopathological examinations of the heart have not revealed any effects in rats fed 2,4-DCP at 2,000 mg/kg/day or in mice fed 2,4-DCP at 2,600 mg/kg/day for 13 weeks (NTP 1989).

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