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Toxicological profiles - Chlorine Dioxide And Chlorite

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Extra info for Toxicological profiles - Chlorine Dioxide And Chlorite

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Gill et al. (2000; results previously published in CMA 1996) conducted a 2-generation study to examine reproductive, developmental, neurological, and hematological end points in rats exposed to sodium chlorite. 6, and 29 mg/kg/day for females. The treatment period lasted for 10 weeks prior to mating and during mating, after which males were sacrificed; exposure of females continued throughout gestation and lactation. Sodium chlorite concentrations were adjusted during lactation to maintain a constant intake during a period of increased water intake.

Dalhamn (1957) also reported death in three of five rats exposed to approximately 10 ppm (28 mg/m3) of chlorine dioxide, 4 hours/day for up to nine exposures in a 13-day period; clinical signs of toxicity included rhinorrhea and altered respiration. In another study, rats were repeatedly exposed for 1 month (15 minutes/exposure, 2 or 4 times/day) to atmospheres containing 15 ppm (42 mg/m3) of chlorine dioxide (Paulet and Desbrousses 1974). Death was noted in 1/10 and 1/15 rats exposed 2 or 4 times/day, respectively.

Mating commenced at approximately 14 weeks of age to produce F2a rats that were maintained through weaning on postnatal day 21. Due to a reduced number of litters in the mid-dose F1-F2a generation, the F1 animals were remated following weaning of the F2a rats to produce an F2b generation. Significant alterations related to treatment at high-dose included reduced absolute and relative liver weight in F1 males and females, reduced pup survival (increase in number of pups found dead and/or killed prematurely during lactation) and reduced body weight at birth and throughout lactation in F1 and F2 rats, lower thymus and spleen weight in both generations, lowered incidence of pups exhibiting normal righting reflex and with eyes open on postnatal day 15, decreased absolute brain weight for F1 males and F2 females, delayed sexual development in F1 and F2 males (preputial separation) and females (vaginal opening), and lowered red blood cell parameters in F1 rats.

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