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Toxicological profiles - Carbon tetrachloride by Agency for Toxic Substances and Disease Registry

By Agency for Toxic Substances and Disease Registry

The ATSDR toxicological profile succinctly signify the toxicological and adversarial wellbeing and fitness results details for the damaging substance defined therein. the focal point of the profiles is on future health toxicological info; for this reason every one toxicological profile starts off with a public health and wellbeing assertion that describes, in nontechnical language, a substance's correct toxicological houses.

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Extra info for Toxicological profiles - Carbon tetrachloride

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Longer-term exposure to concentrations of 1-5 ppm have not been observed to cause any significant changes in liver of rats, monkeys, or guinea pigs (Adams et al. 1952; Prendergast et al. 1967). Based on a NOAEL of 5 ppm (Adams et al. 05 ppm for inhalation exposure to carbon tetrachloride was calculated, as described in the footnote in Table 2-1. Renal Effects. Nephritis and nephrosis are very common effects in humans following inhalation exposure to carbon tetrachloride (Jennings 1955; McGuire 1932; Norwood et al.

3  )    )   -12. )   -12. 8    -151 !  #$: %" 9         Renal Effects. Acute renal failure, as evident by anuria and azoturia, was reported in three case reports of humans after dermal application of carbon tetrachloride-based lotion (Perez et al. 1987). The usefulness of this finding is limited by the lack of data concerning the amount of carbon tetrachloride applied or absorbed. No studies were located regarding renal effects in animals after dermal exposure to carbon tetrachloride.

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