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Extra info for Toxicological profiles - Acrolein
Example text
3 Dermal Exposure No studies were located regarding absorption in humans after dermal exposure to acrolein. 3), effects were restricted to the exposed region of the body, presumably because of the high reactivity of acrolein. Limited information is available regarding dermal absorption of acrolein in animals. The percutaneous LD50 for rabbits ranged from 160 to 1000 mg/kg, depending on the vehicle (Albin 1962). From these limited data, it appears that acrolein is more efficiently absorbed when mineral spirits are used as a vehicle, rather than water.
1979). The usefulness of this study in assessing the neurotoxic effects of oral exposure to acrolein is limited. It is difficult to determine whether these observed effects are direct toxicological effects attributed to acrolein treatment or nonspecific responses of animals in extremis. 5 Developmental Effects No studies were located regarding developmental effects in humans after oral exposure to acrolein. Developmental effects have been observed in animals after oral exposure. Increased incidences of skeletal anomalies and delayed ossification and decreased mean fetal weight and total litter weights were observed in the offspring of rats exposed to 10 mg/kg/d (King 1982).
5 ppm caused biochemical alterations in the nasal respiratory mucosa of rats, but the toxicological significance of this finding is unclear (Lam et al. 1985). 3 ppm acrolein for 2 hours (Leikauf et al. 1989). This increase, however, was not accompanied by a simultaneous increase in neutrophil infiltration, which the authors took to suggest that cells other than neutrophils are responsible for the increase in bronchial responsiveness. Studies regarding respiratory effects after intermediate duration exposure of humans to acrolein were not located in the available literature.
