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Additional info for Toxicological profiles - 1,3-dichloropropene
Example text
Humans exposed to 1,3-dichloropropene after a tank truck spill complained of nausea and vomiting (Flessel et al. 1978), which indicates that gastrointestinal effects are possible. Mice exposed to 60 ppm Telone II®b for 2 years by inhalation developed hyperplasia and hyperkeratosis of the forestomach (Lomax et al. 1989). These gastrointestinal effects were not observed in rats under the same exposure protocol, nor were they observed in mice examined after 6 or 12 months of exposure. Gastrointestinal effects were not observed in other studies of inhalation exposure.
No studies were located regarding hepatic effects in humans after inhalation exposure to l,3-dichloropropene. Gross and histopathological examination of livers did not reveal any differences between exposed and control groups of rats and mice after inhalation exposure to up to 150 ppm of Telone II ®a for 13 weeks or less (Coate et al. 1979b; Stott et al. 1988), up to 50 ppm DD ® for 6-12 weeks (Parker et al. 1982), or up to 60 ppm Telone II®b for 24 months or less (Lomax et al. 1989). Renal Effects.
Humans exposed to 1,3-dichloropropene after a tank truck spill complained of mucous membrane irritation, chest pain, and cough (Flessel et al. 1978). Rats exposed to 1,3-dichloropropene had lung congestion, tracheal congestion, and fluid in the thoracic cavity (Cracknell et al. 1987). Atelectasis, emphysema, and/or pulmonary edema, and lung hemorrhage have been observed in rats exposed to 1,3-dichloropropene vapors (Streeter and Lomax 1988; Streeter et al. 1987). The most consistent pathological finding after inhalation exposure in animals was hyperplasia and/or degeneration of the nasal epithelium (Breslin et al.
