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Therapeutic Ribonucleic Acids in Brain Tumors by Cristóbal Belda-Iniesta, Rosario Perona (auth.), Volker A.

By Cristóbal Belda-Iniesta, Rosario Perona (auth.), Volker A. Erdmann, Guido Reifenberger, Jan Barciszewski (eds.)

In the earlier few years nucleic acids applied sciences have grown right into a robust analytical and in addition more and more healing instrument. it's been utilized not just to the uncovering of gene services in lots of organisms, but in addition to pathogenetic research and lately additionally for the remedy of human illnesses. The ebook discusses intensive the opportunity of those leading edge equipment within the large box of crucial anxious process and mind tumours rather. while there's at the moment no entire review on strength and demanding situations of nucleic acids applied sciences for simple mind tumours and for the scientific administration of sufferers with mind tumours, this ebook does explicitly disguise the various different facets of the "RNA global" (pathogenic and healing strength of microRNAs, aptamer know-how, etc.), too. With this considerably broadened scope in comparison to at the moment latest books it sounds as if to be an urgently wanted new publication.

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25 26 30 35 38 39 40 40 42 44 46 Abstract Malignant gliomas are the most common and most aggressive primary brain tumors in adults. Advances in surgery, radiotherapy and chemotherapy only have a minor impact on the natural course of these tumors. Due to the dismal prognosis of malignant glioma patients, there is an urgent need for new innovative treatments based on a better understanding of the molecular mechanisms of gliomagenesis. Many growth factors, growth factor receptors – usually receptor tyrosine kinases – and receptor-associated intracellular signaling pathways are critically involved in glioma growth, invasiveness and tumor neovascularization.

1 Genetic Pathways of Primary (de novo) and Secondary Glioblastomas . . . . . . . 2 Major Signaling Pathways Regulating Tumor Growth . . . . . . . . . . . . . . . . 3 Major Signaling Pathways Regulating Tumor-Angiogenesis . . . . . . . . . . . . 4 Major Intracellular Signal Transduction Pathways . . . . . . . . . . . . . . . . . . 2 Neoangiogenesis in Malignant Gliomas . . . . . . . . . . . . . . . . . . . . . . . . .

1992a; Shapiro 2001). PDGF receptor and ligand overexpression tend to be associated with TP53 tumor suppressor loss, characteristic of secondary GBMs (Shapiro 2001). 3 TGF/TGF-R Signaling Pathway Transforming growth factor (TGF) a is a polypeptide of the EGF family of peptide growth factors with 30–40% identical sequence homology to EGF and functions as a monomeric ligand of the EGFR (Aaronson 1991; Maher et al. 2001; von Deimling et al. 1995). In high-grade glioma cells, frequent coexpression of TGF-a and EGFR is present, suggesting auto- and paracrine growth stimulation similar to EGF/EGFR and PDGF/PDGFR.

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