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The Metabolic Syndrome: Pharmacology and Clinical Aspects by Henning Beck-Nielsen (auth.), Henning Beck-Nielsen (eds.)

By Henning Beck-Nielsen (auth.), Henning Beck-Nielsen (eds.)

The metabolic syndrome is a typical syndrome affecting approximately 20 % of the grownup inhabitants in Europe, and possibly the superiority is of a similar value in different industrialised nations around the world. it truly is generally as a result of western way of life leading to stomach weight problems, but in addition a genetic predisposition performs a job. This syndrome, that's associated with rest way of life and overeating/obesity, can turn into sort 2 diabetes, heart problems and melanoma. as a result, right therapy and prevention are seriously wanted. This ebook discusses way of life intervention and therapy, in particular with pharmacological compounds, so that it will formulate a method for treating the metabolic syndrome within the day-by-day clinic.

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However, ceramide formation is not the only mediator of lipid-induced metabolic dysfunction. The accumulation of diglycerol is the result of an increase in intracellular triglycerides. Diglycerols activate protein kinase C epsilon and theta (PKCε & PKCθ) that increase the serine phosphorylation of the insulin receptor and insulin receptor substrate 1 (IRS-1). This effect appears to be independent of the ceramide inhibition of Akt/PKB though both result in a decrease in insulin action. The source of diglycerols is not clear with evidence to suggest that saturated and/or polyunsaturated are the main sources of lipid in the diet [79].

The contribution of genetic and epigenetic factors to the metabolic syndrome is not fully understood, but their regulation of gene expression and is likely to play a very important role. 1 Genetics Advances in technology have allowed the human genome to be comprehensively analysed to quantify the genes and sequence variations that might account for the onset and progression of human diseases. In some cases, these approaches have identified monogenic determinants that result in extreme metabolic phenotypes [61].

Television viewing, often used as a surrogate marker of sedentary time, is associated with a dose-dependent increase in the prevalence of the metabolic syndrome as well as increased risk of obesity, type 2 diabetes, hypertension, high triglycerides and low HDL cholesterol [39–41]. Therefore, physical inactivity is likely to be an important contributor to the development of the metabolic syndrome and may offset the benefits of recommended levels of physical activity. It is reasonable to question whether a 30 min bout of exercise, 5 days per week, is enough to offset the impact of 7–8 h of daily sedentary time.

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