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The Global Politics of Intellectual Property Rights and

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Jonker and A. H. Schinkel, J. Pharmacol. Exp. , 2004, 308, 2. G. Englund, F. Rorsman, A. Ronnblom, U. Karlbom, L. Lazorova, J. Grasjo, A. Kindmark and P. Artursson, Eur. J. Pharm. , 2006, 29, 269–277. C. Hilgendorf, G. Ahlin, A. Seithel, P. Artursson, A. L. Ungell and J. Karlsson, Drug Metab. , 2007, 35, 1333. K. M. Giacomini, S. M. Huang, D. J. Tweedie, L. Z. Benet, K. L. Brouwer, X. Chu, A. Dahlin, R. Evers, V. Fischer, K. M. Hillgren, K. A. Hoffmaster, T. Ishikawa, D. Keppler, R. B. Kim, C.

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Recent developments in sophisticated crystallization methods, and utilization of polymeric and surfactant stabilizers make it technically feasible to produce particles in the order of a few hundred nanometers. Nanoparticles comprise polymeric, liposomal, or solid lipid formulated nanoscale drug assemblies, and also include nanosized drug crystals and suspensions. Drug nanoparticles drastically increase the ratio of surface area to mass compared with simple drug powders, and have the potential to provide significant increases in the rate of dissolution.

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