By Harris Busch (Eds.)
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Extra resources for The Cell Nucleus. Volume 2
Example text
In the testicular feminization syndrome, XY individuals present with normal-appearing female external genitalia, blind vagina and inguinal or abdominal testes. Thus it seems certain that genes on either the X and/or the autosomal chromosomes also play a necessary role in male sexual differentiation. At least one X chromosome is required for survival. An X alone results in spontaneous abortion about 98% of the time (Hecht and Macfarlane, 1969). The survivors are females with Turner's syndrome. Turner's syndrome consists of dysplastic ovaries, short stature, and a variable complex of somatic anomalies ( de Grouchy, 1974 ) .
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S. (1968). Science 162, 1105. Miller, D. , Kouri, R. , Dev, V. , Grewal, M. , Hutton, J . J . , and Miller, O. J . ( 1971). Proc. Nat. Acad. Sei. US 68, 2699. Miller, Ο. J . , Allderdice, P. , Miller, D. , Breg, W. , and Migeon, B. R. (1971a). Science 173, 244. Miller, O. J . , Miller, D. , Kouri, R. , Allderdice, P. , Dev, V. , Grewal, M. , and Hutton, J. J . ( 1971b). Proc. Nat. Acad. Sei. S. 68, 1530. Mittwoch, U. ( 1967 ). " Academic Press, New York. , Grumbach, M. , and Taylor, J . H. ( 1 9 6 2 ) .
