By Brian L. Strom, Stephen E. Kimmel, Sean Hennessy
Textbook of Pharmacoepidemiology, moment version, presents an
introduction to pharmacoepidemiology and the information resources, methods
and purposes utilized in medical study, the pharmaceutical industry
and regulatory agencies.
Drawing upon the 5th version of the authoritative reference,
Pharmacoepidemiology, this re-creation covers the major learning
requirements of the self-discipline. The textbook presents an creation to
pharmacoepidemiology, pharmacoepidemiological information assets, special
issues in method, designated functions and destiny advancements in
the box. up to date studying gains reminiscent of case reviews, key issues and
Suggested extra examining are integrated in the course of the text.
Textbook of Pharmacoepidemiology is a pragmatic academic source for
upper-level undergraduates, graduate scholars, post-doctoral fellows in
schools of public overall healthiness, pharmacy and drugs, and for everybody learning
and operating in pharmacoepidemiology.
Read Online or Download Textbook of Pharmacoepidemiology PDF
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Additional resources for Textbook of Pharmacoepidemiology
Sample text
The additional sample size available in postmarketing studies permits the study of drug effects that may be uncommon, but important, such as druginduced agranulocytosis. Premarketing studies are also necessarily limited in time; they must come to an end, or the drug What is Pharmacoepidemiology? could never be marketed. In contrast, postmarketing studies permit the study of delayed drug effects, such as the unusual clear cell adenocarcinoma of the vagina and cervix, which occurred two decades later in women exposed in utero to diethylstilbestrol.
Probably the best-known example was zidovudine. As noted above, the increased sample size available after postmarketing also permits a more precise determination of the correct dose to be used. Premarketing studies also tend to be very artificial. Important subgroups of patients are not typically included in studies conducted before drug marketing, usually for ethical reasons. Examples include the elderly, children, and pregnant women. Studies of the effects of drugs in these populations generally must await studies conducted after drug marketing.
Often they are from a single hospital or medical practice. Alternatively, case series can be collections of patients with a single outcome, looking at their antecedent exposures. For example, one might observe 100 consecutive women under the age of 50 who suffer from a pulmonary embolism, and note that 30 of them had been taking oral contraceptives. After drug marketing, case series are most useful for two related purposes. First, they can be useful for quantifying the incidence of an adverse reaction.
