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Sleep Deprivation, Stimulant Medications, and Cognition

Sleep Deprivation: Stimulant medicines and Cognition offers a overview, synthesis and research of the clinical literature relating stimulant medicines and neurobehavioral functionality, with an emphasis on severely comparing the sensible application of those brokers for preserving cognitive functionality and application in sleep-deprived (but in a different way fit) members.

The e-book explores the character of sleep loss-induced cognitive deficits, neurophysiologic foundation of those deficits, relative efficacy and boundaries of assorted interventions (including non-pharmacological), and implications for employing those interventions in operational environments (commercial and military).

Readers of this quantity will achieve a operating wisdom of: Mechanisms contributing to sleep loss-induced cognitive deficits; Differential results of stimulant compounds on numerous points of cognition; issues (e.g., abuse legal responsibility) while employing stimulant interventions in operational settings; present kingdom and destiny instructions for together with stimulants in accomplished fatigue-management recommendations. this article is vital studying for researchers and trainees in sleep and psychopharmacology."

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However, human studies have typically relied more on measures of sleep onset latency and decrements in vigilance to measure sleepiness (as opposed to EEG measures of delta power or other EEG-based metrics), and this fact may be particularly important when interpreting results from chronic sleep restriction studies conducted to date [19]. Attention/vigilance measures The deficits in alertness and attention produced by sleep loss are of operational concern because they can lead to errors and accidents [3].

J Sleep Res 2000; 9(3): 207–31. [5] Lim J, Wu WC, Wang J, et al. Imaging brain fatigue from sustained mental workload: an ASL perfusion study of the time-on-task effect. Neuroimage. 2010; 49(4): 3426–35. [6] Buxton RB. Quantifying CBF with arterial spin labeling. J Magn Reson Imaging 2005; 22(6): 723–6. [7] Aguirre GK, Detre JA, Zarahn E, Alsop DC. Experimental design and the relative sensitivity of BOLD and perfusion fMRI. Neuroimage 2002; 15(3): 488–500. compensatory response to total sleep deprivation.

Caffeine dose effect on activation-induced BOLD and CBF responses. Neuroimage 2009; 46(3): 577–83. [89] Vandewalle G, Maquet P, Dijk DJ. Light as a modulator of cognitive brain function. Trends Cogn Sci 2009; 13(10): 429–38. [90] Caldwell JA, Prazinko B, Caldwell JL. Body posture affects electroencephalographic activity and psychomotor vigilance task performance in sleepdeprived subjects. Clin Neurophysiol 2003; 114(1): 23–31. [91] Dickerson BC, Sperling RA. Neuroimaging biomarkers for clinical trials of disease-modifying therapies in Alzheimer’s disease.

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