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Salt and Hypertension: Dietary Minerals, Volume Homeostasis by D. Denton, M. McKinley, E. Tarjan, R. Weisinger (auth.), R.

By D. Denton, M. McKinley, E. Tarjan, R. Weisinger (auth.), R. Rettig, D. Ganten, F. C. Luft (eds.)

Controversy in regards to the knowledge of a excessive salt consumption has been with us for 5000 years. within the Nei Ching, the oldest of the extant scientific writings, the Yellow Emperor saw, "Hence, if an excessive amount of salt is within the nutrients, the heart beat hardens, tears make their visual appeal, and the complexion changes". At concerning the related interval in historical past, activity requested the query, "Can that that's unsavory be eaten with no salt?" it's not obvious even if the Almighty supplied a transparent resolution. the relationship among nutritional salt consumption and high blood pressure used to be preferred following the observations of AMBARD, BEAUJARD, VOLLHARD, ALLEN, and others. despite the fact that, DAHL emphasised this courting, as established via his epidemiological observations, his stories in human matters, and his improvement of a genetically mediated type of salt-sensitive high blood pressure in rats. DAHL and his fans argued that high blood pressure used to be a affliction of acculturation, or maybe of self-abuse. Undaunted via skeptics resembling PICKERING, they recommended that if Western guy may only curtail his consumption of the granular condiment, high blood pressure wouldn't enhance and blood strain wouldn't bring up with age. Bucolic local societies got as examples the place such cardiovascular bliss was once effortlessly attained.

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Additional resources for Salt and Hypertension: Dietary Minerals, Volume Homeostasis and Cardiovascular Regulation

Example text

From the presented data we suppose that the characterized ion channel which becomes activated in response to mechanical and osmotic stress is identical and might be involved in proximal tubular cell volume homeostasis. + which mediates an outward rectifying K current. Part of this work appeared in abstract form (UBL et a1. 1988). Material and Methods Cell Culture OK cells (KOYAMA et a1. 1978) were originally obtained from DR. D. G . WARNOCK (San Francisco, CA) at serial passage 79, and experiments were performed using cells between passage 86 and 100.

J Membr Bioi 78:211-222 Kirk KL, Schafer JA, DiBona DR (1987a) Cell volume regulation in rabbit proximal straight tubule perfused in vitro. Am J PhysioI252:F922-F932 Kirk KL, DiBona DR, Schafer JA (1987b) Regulatory volume decrease in perfused proximal nephron: evidence for a dumping of cell K. Am J PhysioI252:F933-F942 Knoblauch CH, Montrose MH, Murer H (1988) Regulatory volume decrease by cultured renal cells (OK). : in press Koyama H, Goodpasture MM, Teplitz RL, Riggs AD (1978) Establishment and characterization of a cell line from the American opossum (Didelphys virginiana).

Am J PhysioI159:369-376 I 22 E. Ritz, 1. Mann, and M. Schmid Starling EH, Verney EB (1925) The secretion of urine as studied on the isolated kidney. Proc R Soc Lond 97:321-363 Stein lH, Osgood RW, Boonjarern S, Ferris PF (1973) A comparison of segmental analysis of sodium reabsorption during Ringer's and hyperoncotic albumin infusion in the rat. 1 Clin Invest 52:2313-2323 Strauss MB, Lambdin E, Smith WP, Bleifer Sl (1958) Surfeit and deficit of sodium. Arch Intern Med 102:527-536 Victor RG, Morgan DA, Thoren P, Mark A (1986) High salt diet sensitizes cardiopulmonary baroreflexes in Dahl salt-resistant rats.

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