By Harry G. Brittain
Even supposing the reputable compendia outline a drug substance as to id, purity, energy, and caliber, they typically don't supply different actual or chemical info, nor do they checklist equipment of synthesis or pathways of actual or organic degradation and metabolism. Such details is scattered in the course of the clinical literature and the documents of pharmaceutical laboratories. Edited via the affiliate Director of Analytical study and improvement for the yank organization of Pharmaceutical Scientists, Analytical Profiles of Drug elements and Excipients brings this knowledge jointly into one resource. The scope of the sequence has lately been improved to incorporate profiles of excipient fabrics.
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6 2. Method of Preparation 3. 4 Mass Spectrometry 4. 5 5. 3 Incompatibilitieswith Functional Groups 6. 4 Elimination 7. Toxicology 8. References 49 REX HALL ET AL. 50 1. 5 Appearance White to off-white crystals or powder. 6 Uses and Applications Azoptm (brinzolamide ophthalmic suspension) 1% is a topical carbonic anhydrase inhibitor (CAI) indicated for the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma [3-61. In double-masked, controlled clinical trials, Azopt therapy was demonstrated to be safe, welltolerated.
71, 354 (1982). 48. K. S. Pang, Drug Metab. Disp,, 23, 255 (1994). 49. A. Rougier, C . I. Maibach, J. Pharrn. , 76, 451 (1 987). 50. D. J. D. Marrow, Clin. Pharmacol. , 57, 441 (1995). 46 GUNAWAN INDRAYANTO ET AL. 51. J. J. McCarthy, J. Clin. Pharm. , 12, 107 (1 987). 52. A. M. H. , 8, 157 (1955). BRINZOLAMIDE Rex Hall', Grey Wavner', John Baker', Glenn Stafford2, Wayne Schneider2, Way-Yu Lin2, Jesse May3, Michael Curtis4,Craig Struble4, Bette McCue4, Dan Jasheway4, and David McGee' (1) Analytical Chemistry (2) Research SuppodPharmaceutics (3) Research/Discovery Synthesis (4)PharmacokineticslDrug Metabolism ( 5 ) Toxicology Research and Development Alcon Laboratories, Inc.
16. Europaeisches Arzneibuch 1997, 3, Auflage, Duetscher Apotheker Verlag, Stuttgart, 1997. 17. 0. Volvord, M. Takacs, and J. Vamos, Acta Pharm. , 66, 133 (1996). 18. Z. Li, Chin. J. , 10, 312 (1992). 19. I. Krull and R. Martissek, Deutsche Leben. , 84, 144 (1988). 20. W. Haensel and R. Stroemmer, GIT Suppl. , 3, 2 1 (1987). 21. Y . Zuying, Chin. Brew, 2, 32 (1983). 22. V. G. Roche, Elelmiszewizsgalati Koezlemenyek, 28, 2 13 (1982). 44 G U N A W A N lNDRAYANTO ET AL. 23. W. Ponder, S. Cliett, E.