By Robert M. Julien, Claire D. Advokat, Joseph Comaty
Version after variation, Robert Julien’s A Primer of Drug motion keeps velocity with probably the most dynamic fields of medical inquiry, giving scholars rapid entry to the most up-tp-date study and promising new instructions in psychopharmacology. conscientiously up to date all through, the recent variation back takes its position because the definitive consultant to the medication that impact the brain and behaviour. As consistently, it really is transparent, entire, aim, and authoritative, spanning a wide selection of drug forms, together with sedatives, depressants, stimulants, analgesics, psychedelic medicinal drugs, steroids, and medication used to regard mental problems.
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Extra resources for Primer of Drug Action (12th Edition)
Sample text
Behavioral conditioning processes are the third type of drug tolerance. The exposure of drugs to receptors does not account for the substantial degree of tolerance that many people acquire to opioids, barbiturates, ethyl alcohol, and other drugs. Instead, tolerance can be demonstrated when a drug is administered in the context of usual predrug cues but not in the context of alternative cues. Poulos and Cappell (1991) proposed a homeostatic theory of drug tolerance. They found that, with morphine analgesia, testing in an environment in which tolerance had developed affected the manifestation of tolerance, and an environmental cue could maintain the tolerance.
Et al. (2009). 1177/0269881109106957. Gilstrap, L. , and Little, B. B. (1998). Drugs and Pregnancy, 2nd ed. New York: Chapman & Hall. Greenblatt, D. , et al. (1999). ” Journal of Clinical Psychopharmacology 19, Supplement 1: 23S–35S. Greenblatt, D. , et al. (2003). ” Clinical Pharmacology and Therapeutics 74: 121–129. Lilja, J. , et al. (1998). ” Clinical Pharmacology and Therapeutics 64: 655–660. Lin, K. , et al. (2001). ” Psychiatric Clinics of North America 24: 523–538. Paine, M. , et al. (2006).
Binding to a receptor site normally occupied by a neurotransmitter, but not initiating a transmitterlike action, blocks access of the transmitter to its binding site, which inhibits the normal physiological action of the transmitter. This is called an antagonistic action, and the drug is termed an antagonist for that neurotransmitter or receptor site. It is also a general rule of psychopharmacology that drugs do not create any unique effects; they merely modulate normal neuronal functioning, mimicking or antagonizing the actions of a specific neurotransmitter.
