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Pharmacology of Peptic Ulcer Disease by G. Sachs, P. N. Maton, B. Wallmark (auth.), Martin J. Collen

By G. Sachs, P. N. Maton, B. Wallmark (auth.), Martin J. Collen M.D., F.A.C.P., Stanley B. Benjamin M.D., F.A.C.P. (eds.)

In this ebook the pathophysiology, analysis, and remedy of so much points of peptic ulcer sickness are tested intimately. lined are the pharmacology of the parietal mobilephone and the newest hypotheses for the advance of acid-peptic sickness together with epidermal development issue, gastrin and different peptide hormones, fatty acids and prostaglandins, helicobacter pylori, and gastric acid hypersecretion together with Zollinger-Ellison syndrome. The ebook additionally bargains with the more recent antisecretory drugs reminiscent of omeprazole with a evaluate of H2-receptor antagonists. Rounding off the topic are chapters on gastroesophageal reflux disorder, higher GI endoscopy, and videoendoscopy together with electronic imaging. This quantity addresses a variety of physicians who're drawn to all features of acid-peptic illness. What distinguishes this quantity from others is the well timed replace on a couple of vital matters referring to acid-peptic affliction. not just does it evaluation a few themes which are of serious curiosity this day, however it introduces an unlimited volume of latest unpublished data.

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It is equally possible that the sidedness and affinity of the sites change due to twisting and untwisting of protein helices, a peristaltic model. Both models are illustrative of a chemomechanical pump. As shown in both the catalytic cycle and the graphic model, the initial binding is that of a proton, presumably to histidine. The site is large enough, however, to accommodate water. In the E2 form of the site, the histidine is not present and the released cation, bound to carbonyl oxygens, is the hydronium ion H30+.

J Bioi Chern 262:2077-2084 Walsh JH (1987) Gastrointestinal hormones. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven, New York, pp 181-253 Whittle BJR, Vane JR (1987) Prostanoids as regulators of gastrointestinal function. In: Johnson LR (ed) Physiology of the gastrointestinal tract. Raven, New York, pp 142-180 Wilkes J: Kajimura M, Scott DR, Hersey SJ, Sato G (1991) Parietal cell response to muscarinic antagonists. J Membr Bioi (in press) Wolosin JM (1985) Ion transport studies with HK ATPase rich vesicles.

Methods Exp Clin Ph arm 11:113-116 Mercier F, Besancon M, Hall K, Sachs G (1991) Location of omeprazole binding to the H+ ,K+ -ATPase under transport conditions, J Bioi Chern (submitted) Muallem S, Sachs G (1985) Ca metabolism during cholinergic stimulation of acid secretion. Am J Physiol 248:G216-G228 34 G. SACHS et al. Regulation of free cytosolic Ca in the peptic and parietal cells of the rabbit gastric gland. J Bioi Chern 261:26602667 Muallem S, Blissard D, Cragoe EM, Sachs G (1988) Activation of Na/H and ClIHC03 exchange by stimulation of acid secretion by the parietal cell.

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