By Toshimitsu Niwa, Mitsuharu Kajita, Toshiharu Nagatsu (auth.), Andreas Moser (eds.)
It is a brilliant excitement to put in writing the foreword to this significant quantity for numerous purposes. First: so far as we all know, already primitive societies needed to take care of environmental pollutants of many varieties and organize rules to restrict their results on nutrients and drug use. Modem technological know-how, synthesizing hundreds of thousands of latest compounds has really magnified this problem. at the present time, xenobiotic metabolism has develop into a vital activity for people and lots of different species alike. moment: whilst studying this ebook, one is inspired by way of the intense pace at which neurotoxicology has complex. evidently, processing (and endogenous formation) oftox ins has turn into an exceptionally appropriate subject. while I had the opportunity, nearly 3 many years in the past, to paintings in chemical pharmacology with Bernard B. Brodie at NIH, the drug metabo lizing method of the liver had simply been well-known and characterised. We had simply began to paintings at the biogenic amines, newly found cyclic nucleotides in rat mind, human cere brospinal fluid, and at the results of poisonous medicines like amphetamines. this present day, biochemical neuropharmacology is a mature box of neuroscience.
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Extra info for Pharmacology of Endogenous Neurotoxins: A Handbook
Example text
1996) examined N-methyl-R-salsolinol (IR,2-dimethyl-6, 7-dihydroxy-l ,2,3,4tetrahydroisoquinoline) and salsolinol for their neurotoxicity for dopaminergic neurons by stereotaxic injections into the left corpus striatum of male Wistar rats. 100 nmol of the compounds dissolved in Ringer solution were injected into the rat striatum at a flow rate of 1 ",,112 min (total volume 5 ",,1). Only N-methyl-R-salsolinol induced behavioral changes very similar to those found in Parkinson's disease, including hypokinesia; stiff tail, limb twitching, and postural abnormalities.
Neurosci. Lett. 91:349-353. , and Ikebe S. (1994) An immunohistochemical study on a-ketoglutarate dehydrogenase complex in Parkinson's disease. Ann. Neurol. 35:204-210. , and Kompf D. (1992) Presence of methy 1-6,7-dihydroxy-l ,2,3,4-tetrahydroisoquinolines, derivatives of the neurotoxin isoquinoline, in parkinsonian lumbar CSF. Life Sci. 50:1885-1891. , and Bamberg H. (1995) Presence of N-methyl-norsalsolinol in the CSF: correlations with dopamine metabolites of patients with Parkinson's disease.
1980) Neuroamine condensations in human subjects. Adv. Exp. Med. BioI. 126:87-102. , and Origitano TC. (1983) Catecholamine-derived tetrahydroisoquinolines: O-methylation patterns and regional brain distribution following intraventricular administration in rats. 1. Neurochem. 41:1569-1575. , and Naoi M. (1995) Determination of the (R)- and (S)-enantiomers of salsolinol and N-methylsalsolinol by use of a chiral high-performance liquid chromatographic column. 1. Chromatogr. 670: 47-54. , and Vernay D.
