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Nanotechnology-Based Precision Tools for the Detection and by Chad A. Mirkin, Thomas J. Meade, Sarah Hurst Petrosko,

By Chad A. Mirkin, Thomas J. Meade, Sarah Hurst Petrosko, Alexander H. Stegh

This ebook discusses rising nanotechnology-based instruments that experience the aptitude to dramatically impression melanoma study, diagnostics, and remedy. melanoma is a posh, devastating, and debilitating ailment and, even if a lot development has been made, novel, more advantageous diagnostic and remedies are nonetheless wanted, specially for complex cancers. the final word target is to discover melanoma early and non-invasively and to supply efficacious and certain precision remedies that reason fewer damaging uncomfortable side effects. This booklet explains how nanotechnology can make the most the size-, shape-, and composition-dependent houses of nanomaterials to supply novel instruments for precision melanoma drugs. will probably be of curiosity to researchers and execs operating within the fields of chemistry, biology, fabrics technological know-how and engineering, and medication who are looking to study extra approximately this interesting and fast moving region of research.

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Mirkin CA, Letsinger RL, Mucic RC, Storhoff JJ (1996) A DNA-based method for rationally assembling nanoparticles into macroscopic materials. Nature 382:607–609 16. Cutler JI, Zheng D, Xu X, Giljohann DA, Mirkin CA (2010) Polyvalent oligonucleotide iron oxide nanoparticle “Click” conjugates. Nano Lett 10:1477–1480 17. Zhang C, Macfarlane RJ, Young KL, Choi CHJ, Hao L, Auyeung E, Liu G, Zhou X, Mirkin CA (2013) A general approach to DNA-programmable atom equivalents. Nat Mater 12:741–746 Nanoflares as Probes for Cancer Diagnostics 21 18.

GdIII signal is white and outlined with a black dotted line. 5-SNAs. SNA accumulation is indicated by increased fluorescence (yellow). Quantification of radiant efficiency is shown as relative signal amount under the images. SiCo = scrambled control sequences. Adapted with permission from Jensen et al. [45]. Copyright 2013. Science Translational Medicine Therapeutic Applications of Spherical Nucleic Acids 31 demonstrated that Bcl2L12-targeting SNAs (L12-SNAs) were able to undergo transcytosis through the huBMEC layer and enter human astrocytes (Fig.

Nano Lett 7:2112–2115 15. Mirkin CA, Letsinger RL, Mucic RC, Storhoff JJ (1996) A DNA-based method for rationally assembling nanoparticles into macroscopic materials. Nature 382:607–609 16. Cutler JI, Zheng D, Xu X, Giljohann DA, Mirkin CA (2010) Polyvalent oligonucleotide iron oxide nanoparticle “Click” conjugates. Nano Lett 10:1477–1480 17. Zhang C, Macfarlane RJ, Young KL, Choi CHJ, Hao L, Auyeung E, Liu G, Zhou X, Mirkin CA (2013) A general approach to DNA-programmable atom equivalents. Nat Mater 12:741–746 Nanoflares as Probes for Cancer Diagnostics 21 18.

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