By José Marín-García (eds.)
The functionality of the center is extremely depending on oxidative strength that's generated in mitochondria. Defects in mitochondrial constitution and serve as are available in organization with cardiovascular ailments. Mitochondria and the guts discusses the position that mitochondria performs in heart problems, together with biogenesis and serve as of cardiac mitochondria in the course of common development, improvement and getting older. furthermore, nonbioenergetic, biogenesis and degradation pathways are explored. knowing those pathways and the results that mitochondrial defects have in cardiac pathology is intensely vital in developing the prognosis and remedy of mitochondrial-based cardiac diseases.
José Marín-García is affiliated with The Molecular Cardiology and Neuromuscular Institute, Highland Park, New Jersey and the dep. of body structure & Biophysics, UMDNJ – Robert wooden Johnson scientific university, Piscataway, New Jersey.
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Sample text
Also shown is the proton pump. tronic paramagnetic resonance [EPR] structures) [4]. 2. 3). The 2 largest subunits comprise the succinate dehydrogenase (SDH) activity of the TCA cycle, which catalyzes succinate oxidation to fumarate, thereby reducing covalently attached flavin adenine dinucleotide (FAD). 3. Schematic representation of complex II succinate-ubiquinone oxidoreductase. , succinate); SDH comprises the Fp andlp subunits. ming ubiquinone. Hence it represents a pivotal link between the TCA cycle and the ETC.
2. Schematic view of the structure of complex I. The two major domains of this L-shaped complex enzyme (containing over 40 polypeptides) are shown and contain the NADH and FMN binding sites and the Fe-S clusters Nla, Nib, N2, N3, and N4, which direct the electron flow to the mobile carrier Q (ubiquinone) pool. Also shown is the proton pump. tronic paramagnetic resonance [EPR] structures) [4]. 2. 3). The 2 largest subunits comprise the succinate dehydrogenase (SDH) activity of the TCA cycle, which catalyzes succinate oxidation to fumarate, thereby reducing covalently attached flavin adenine dinucleotide (FAD).
Halestrap AP, Clarke SJ, Javadov SA (2004) Mitochondrial permeability transition pore opening during myocardial reperfusion: A target for cardioprotection. Cardiovasc Res 61:372—85 62. O'Rourke B (2004) Evidence for mitochondrial K+ channels and their role in cardioprotection. Circ Res. 94:420-32 63. Oldenburg O, Cohen M, Yellon D, Downey J (2002) Mitochondrial K(ATP) channels: Role in cardioprotection. Cardiovasc Res 55:429-3764. An Introduction to Mitochondria and the Heart 23 64. Schulz R, Cohen MV, Behrends M, Downey JM, Heusch G (2001) Signal transduction of ischemic preconditioning.
