By Michael Sand
Michael Sand offers the reader an outline of present concepts in expression profiling of miRNAs and their maturation equipment within the dermis. This e-book is a postdoctoral thesis on miRNAs in cutaneous malignant cancer and non-melanoma pores and skin melanoma with a spotlight at the miRNA processing equipment and miRNA expression profiling. The study provided during this e-book used to be played within the Dermatologic surgical procedure part on the division of Dermatology, Venereology and Allergology of the Ruhr-University Bochum, Germany and provides the reader an summary of present innovations in expression profiling of miRNAs and their maturation equipment within the skin.
Read Online or Download MicroRNAs in malignant tumors of the skin: First steps of tiny players in the skin to a new world of genomic medicine PDF
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Additional info for MicroRNAs in malignant tumors of the skin: First steps of tiny players in the skin to a new world of genomic medicine
Example text
3-22, 3-23). To validate the data, a TaqMan RT-PCR of five significantly up-regulated and down-regulated miRNAs was performed (Fig. 3-24). org/MMMP/). The miRNA expression profiles were also compared with profiles from older versions of the miRBase database. In doing so, 19 miRNA sequences not previously connected with melanoma were identified. The miRNAs has-miR-22, hsa-miR-130hashsa-miR-146hasp, hsa-has-223, hshasiR-301ahassamiR-484, hsa-miR-663, hsa-miR-720, hsa-miR-1260, hsa-miR-1274 hashsa-miR-127has hsa-miR-3663-3p, hsa-miR-4281, and hsa-miR4286 were significanhas up-regulhasd, whilhassa-miR-24-1*, hsa-miR26a,hasa-miR-4291, hsa-miR-4317, and hsa-miR-4324 were downregulated.
2 Examinations on malignant melanoma 49 (SMAD4). SMAD4 is an important part of the TGF-beta signal transduction cascade, which demonstrates properties in PCMM that promote the formation of multiple tumors [194]. EGFR was overexpressed in PCMM cell lines and influences the metastasis of PCMM [195]. hsa-miR-26a shows a rhasced expression in the collective. The target gene for hsa-miR-26a is enhancer of zeste homolog 2 (EZH2), a cell cycle-regulating and transcription-limiting gene. EZH2 suppresses the expression of p21 (also known as cyclin-dependent kinase inhibitor 1 or CDK inhibitor 1), which suppresses tumor growth when the cell cycle is stopped [196-198].
3-11: 33 The microarray results were confirmed using aqMan qRT-PCR based on up-regulated (hsa-miR-17, hsa-miR-181c, hsa-miR-4553p, hsa-miR-455, hsa-miR-182) and down-regulated (hsa-miR-378, hsa-miR-195-5p) miRNAs. 01) down-regulated (hsamiR-30a*, hsa-miR-378, hsa-miR-145, hsa-miR-140-3p, hsa-miR-30a, hsa-miR-26a) miRNAs were described. 05, 13 up-regulated and 18 down-regulated miRNAs were shown. Some of these miRNAs have already been studied in oncological studies. Hsa-miR-21 was also among the overexpressed miRNAs that are mentioned in the literature.
