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Metronomic Chemotherapy: Pharmacology and Clinical by Guido Bocci, Giulio Francia

By Guido Bocci, Giulio Francia

This ebook analyzes all points of metronomic chemotherapy, a brand new method related to low-dose, long term, and regularly administered treatment that has preclinical and medical job in numerous tumors. After a gap part at the pharmacological bases of metronomic chemotherapy, together with its antiangiogenic results and influence on immunity, preclinical reports on a variety of sessions of drug are mentioned. medical functions of metronomic chemotherapy in a wide selection of tumors are then addressed intimately, with description of the result of all released reports. The scientific pharmacology of metronomic chemotherapy is additionally thought of intensive, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and opposed drug reactions. The ebook closes by way of describing the function of this remedy within the veterinarian clinic.

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Extra info for Metronomic Chemotherapy: Pharmacology and Clinical Applications

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This study also discusses additional results from various trials demonstrating the additional or even synergistic antitumor effects of LDM chemotherapy when combined with antiangiogenic drugs. For example, LDM topotecan in combination with pazopanib, a small-molecule inhibitor of angiogenesis, resulted in a significant increase in antitumor activity, due in part to reduced tumor microvessel density. The antiangiogenic effects seen in this study were related to the inhibition of systemic angiogenesis rather than inhibiting local antiangiogenic activity in treated tumors.

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