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Martin's Physical Pharmacy and Pharmaceutical Sciences (6th by Patrick J. Sinko

By Patrick J. Sinko

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ISBN: 0781797667 | ISBN-13: 9780781797665 | eISBN: 1451158785 | eISBN-13: 9781451158786 | variation: 6
Publication Date: March 2010
Publisher: Lippincott Williams & Wilkins

Martin's actual Pharmacy and Pharmaceutical Sciences is taken into account the main finished textual content to be had at the program of the actual, chemical and organic ideas within the pharmaceutical sciences. It is helping scholars, academics, researchers, and business pharmaceutical scientists use parts of biology, physics, and chemistry of their paintings and research. because the first version used to be released in 1960, the textual content has been and is still a required textual content for the middle classes of Pharmaceutics, Drug supply, and actual Pharmacy. The 6th variation positive factors extended content material on drug supply, stable oral dosage varieties, pharmaceutical polymers and pharmaceutical biotechnology, and up to date sections to hide advances in nanotechnology.

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Additional resources for Martin's Physical Pharmacy and Pharmaceutical Sciences (6th Edition / 50th Anniversary Edition)

Example text

A rather thorough study of the two polymorphic forms of carbamazepine was made using infrared spectroscopy, thermogravimetric analysis (TGA), hot-stage microscopy, dissolution rate, and x-ray powder diffraction. The hydrogen-bonded structure of the α polymorph of carbamazepine is shown in Figure 2–10a and its molecular formula in Figure 2–10b. Estrogens are essential hormones for the development of female sex characteristics. When the potent synthetic estrogen ethynylestradiol is crystallized from the solvents acetonitrile, methanol, and chloroform saturated with water, four different crystalline solvates are formed.

These deviations reflect the activities of the component(s) within the system. Simply put, fugacity is a measurement of the activity associated with nonideal interactions. For further details pertaining to fugacity and its effects on gases, the student is directed to any introductory physical chemistry text. THE LIQUID STATE Liquefaction of Gases When a gas is cooled, it loses some of its kinetic energy in the form of heat, and the velocity of the molecules decreases. If pressure is applied to the gas, the molecules are brought within the sphere of the van der Waals interaction forces and pass into the liquid state.

The triglyceride tristearin proceeds from the low-melting metastable alpha (α) form through the beta prime (β ) form and finally to the stable beta (β) form, having a high melting point. The transition cannot occur in the opposite direction. Theobroma oil, or cacao butter, is a polymorphous natural fat. Because it consists mainly of a single glyceride, it melts to a large degree over a narrow temperature range (34◦ C–36◦ C). 5◦ C. Riegelman12 pointed out the relationship between polymorphism and the preparation of cacao butter suppositories.

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