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Lung Transplantation by Nicholas R. Banner, Julia M. Polak, Magdi H. Yacoub

By Nicholas R. Banner, Julia M. Polak, Magdi H. Yacoub

This ebook offers a close account of the rules and perform of up to date lung transplantation. An entire, foreign staff of contributing authors have mixed their services to supply the newest clinical advancements and medical wisdom in accordance with their broad event. The publication covers pulmonary vascular and parenchymal lung sickness, which necessitate transplantation, including all points of the multidisciplinary administration of lung transplant sufferers. It concludes by way of taking a look at destiny advancements within the therapy of complicated breathing failure.

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Clear upregulation of RNA for the VEGF receptor Flt-1 can be seen, as well as for the angiopoietin receptor Tek. 4). In addition, work on animal models supports a role for prostacyclin in the pulmonary vascular response to chronic hypoxia. Transgenic mice that overexpress the prostacyclin gene are protected against the development of hypoxic pulmonary hypertension while prostacyclin receptor knockout mice are reported to develop more severe pulmonary hypertension and vascular remodelling than their wild-type counterparts in response to chronic hypoxia [100,101].

Primary pulmonary hypertension. WHO Reg Publ Eur Ser 1975; 7–45. 2 Rich S, Dantzker DR, Ayres SM, et al. Primary pulmonary hypertension. A national prospective study. Ann Intern Med 1987; 107: 216–223. Pathology of pulmonary hypertension 3 Higenbottam TW, Spiegelhalter D, Scott JP, et al. Prostacyclin (epoprostenol) and heart–lung transplantation as treatments for severe pulmonary hypertension. Br Heart J 1993; 70: 366– 370. 4 Adams W, Veith I. Pulmonary circulation. Grune & Stratton, New York.

Papapetropoulos A, Garc´ıa-Cardena G, Madri JA, Sessa WC. Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest 1997; 100: 3131–3139. Ziche M, Morbidelli L, Choudhuri R, et al. Nitric oxide synthase lies downstream from vascular endothelial growth factorinduced but not basic fibroblast growth factor-induced angiogenesis. J Clin Invest 1997; 99: 2625–2634. Murohara T, Asahara T, Silver M, et al. Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.

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