By Yasumasa Nishimura, Ritsuko Komaki
Successful medical use of intensity-modulated radiation remedy (IMRT) represents an important enhance in radiation oncology. simply because IMRT can convey high-dose radiation to a aim with a discounted dose to the encircling organs, it might enhance the neighborhood keep watch over fee and decrease toxicities linked to radiation remedy. because IMRT started getting used within the mid-1990s, a wide quantity of scientific facts of some great benefits of IMRT has been accumulated. in spite of the fact that, therapy making plans and caliber coverage (QA) of IMRT are complex and hard for the clinician and the clinical physicist. This ebook, by means of authors well known for his or her services of their fields, offers cumulative scientific proof and applicable innovations for IMRT for the clinician and the physicist. half I offers with the principles and strategies, historical past, ideas, QA, remedy making plans, radiobiology and similar points of IMRT. half II covers medical functions with numerous case reports, describing contouring and dose distribution with scientific effects in addition to descriptions of symptoms and a overview of medical proof for every tumor web site. the data provided during this publication serves as a necessary source for the practising clinician and physicist.
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Additional resources for Intensity-Modulated Radiation Therapy: Clinical Evidence and Techniques
This optimal intensity is then used to create the MLC leaf positions (leaf positions as a function of time/monitor units [MUs]) that will deliver a fluence that is as close as possible to the optimized distribution. In step-and-shoot multifield IMRT, modulated delivery is achieved with multiple static MLC segments, with each segment having its own aperture shape and weight (MU). The leaf-sequencing algorithm first coverts the optimized intensity distribution to discrete levels, which are then converted into separate MLC segments (Fig.
American Association of Physicists in Medicine, Madison Boyer AL, Yu CX (1999) Intensity-modulated radiation therapy with dynamic multileaf collimators. Semin Radiat Oncol 9(1):48–59 Brenner DJ, Curtis RE, Hall EJ, Ron E (2000) Second malignancies in prostate carcinoma patients after radiotherapy compared with surgery. Cancer 88(2):398–406 Bresciani S, Di Dia A, Maggio A, Cutaia C, Miranti A, Infusino E, Stasi M (2013) Tomotherapy treatment plan quality assurance: the impact of applied criteria on passing rate in gamma index method.
Int J Radiat Oncol Biol Phys 67(4):1248–1258 2. Allen AM, Czerminska M, Jänne PA, Sugarbaker DJ, Bueno R, Harris JR, Court L, Baldini EH (2006) Fatal pneumonitis associated with intensity-modulated radiation therapy for mesothelioma. Int J Radiat Oncol Biol Phys 65(3):640–645 3. Basran PS, Woo MK (2008) An analysis of tolerance levels in IMRT quality assurance procedures. Med Phys 35(6):2300–2307 4. Beadle BM, Liao K-P, Elting LS, Buchholz TA, Ang KK, Garden AS, Guadagnolo BA (2014) Improved survival using intensity-modulated radiation therapy in head and neck cancers: a SEER-Medicare analysis.