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Handbook of drug monitoring methods : therapeutics and drugs by Amitava Dasgupta

By Amitava Dasgupta

Written in a guide type with particular equipment and pointers on taking out fake confident and fake adverse effects, this booklet is a realistic advisor to the designated mechanisms of such occurrences.

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55. Miners JO, Attwood J, Birkett DJ. Influence of sex and oral contraceptives on paracetamol metabolism. Br J Clin Pharmacol 1983; 16: 503–509. 56. Koski A, Vuori E, Ojanpera I. Relation of postmortem blood alcohol and drug concentrations in fetal poisonings involving amitriptyline, propoxyphene and promazine. Hum Exp Toxicol 2005; 24: 389–396. 57. Song BJ. Ethanol inducible cytochrome P450 (CYP2E1): biochemistry, molecular biology and clinical relevance-an update. Alcoholism Clin Exp Res 1996; 20 (Suppl 8): 136A–146A.

Pathway selective sex differences in the metabolic clearance of propranolol in human subjects. Clin Pharmacol Ther 1989; 46: 257–263. 52. Lew KH, Ludwig EA, Milad MA, Donovan K. Gender based effects on methylprednisolone pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther 1993; 54: 402–414. 53. Wolbold R, Klein K, Burk O, Nussler AK, et al. Sex is a major determinant of CYP3A4 expression in human liver. Hepatology 2003; 38: 978–988. 54. Bebia Z, Buch SC, Wilson JW, Frye RF, et al. Bioequivalence revisited: influence of age and sex on CYP enzymes.

Since the 1960s, 5-fluorouracil has been used either alone or as part of a combination therapy with other drugs to treat various solid tumors and is also a standard therapy for colorectal cancer. Pharmacoki- 32 Dasgupta netic studies showed that clinical response as well as toxicity of 5-fluorouracil are related to AUC. Individual dosage adjustments based on pharmacokinetic monitoring lead to higher response rate of this drug as well as survival rates associated with tolerability. A limited sampling strategy using just two plasma concentrations can be used to predict AUC of 5-fluorouracil (165).

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