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Guide to Targeted Therapies: EGFR mutations in NSCLC by Federico Cappuzzo

By Federico Cappuzzo

Guide to unique treatments: EGFR Mutations in NSCLC is a quick and up to date overview, which discusses EGFR mutations, trying out tools and expertise, present and rising cures, and assets that clinicians delivers to their sufferers. Busy healthcare pros who need a fast evaluation of EGFR gene mutations in addition to a precis of present treatments will reap the benefits of this succinct guide.

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Extra resources for Guide to Targeted Therapies: EGFR mutations in NSCLC

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Although these new techniques are improving our ability to detect EGFR mutations, in many cases, after completing all the standard diagnostic procedures, there is no material available for biomarker analysis. In such cases a new tumor biopsy should be performed. Several groups are investigating the possibility of performing biomarker analyses, including EGFR mutation testing, in circulating tumor cells (CTCs) or in circulating DNA. The ability to accurately detect somatic cancer DNA alterations from CTCs or from cell free circulating plasma tumor DNA (ptDNA) using next generation genomic technologies has many potential applications for clinical oncology.

2010;30:5233-5237. Simonetti S, Molina MA, Queralt C, et al. Detection of EGFR mutations with mutation-specific antibodies in stage IV non-small-cell lung cancer. J Transl Med. 2010;8:135. Soh J, Toyooka S, Aoe K, et al. Usefulness of EGFR mutation screening in pleural fluid to predict the clinical outcome of gefitinib treated patients with lung cancer. Int J Cancer. 2006;119:2353-2358. Kimura H, Fujiwara Y, Sone T, et al. High sensitivity detection of epidermal growth factor receptor mutations in the pleural effusion of non-small cell lung cancer patients.

3 months), thus suggesting that cetuximab could improve the efficacy of cisplatin–vinorelbine. This hypothesis was further tested in the FLEX (First-Line ErbituX in lung cancer) trial, a randomized phase III study of cisplatin–vinorelbine with or without cetuximab performed in 1125 patients with EGFR-expressing NSCLC in the first-line setting [9]. 044) with an increased risk of adverse events, particularly febrile neutropenia. Similar results were observed in the BMS099 trial, a phase III trial that randomly assigned 676 chemotherapy-naïve patients with NSCLC to carboplatin plus a taxane versus the same chemotherapy regimen plus cetuximab [10].

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