By Claude Gaultier
Genetic foundation for breathing keep watch over issues emphasizes the powerful synergy among human reviews and mouse versions of genetic issues underlying respiration keep an eye on anomalies. The evaluate of present study provided during this publication opens up the sphere to the improvement of recent healing recommendations, specifically in newborns and babies, who're the first aim of breathing keep watch over issues. This publication is addressed to pediatricians, neonatologists, pulmonologists, respiration physiologists in addition to geneticists.
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Additional info for Genetic Basis for Respiratory Control Disorders
J Magn Reson Imaging 24: 1252-1258 Kumar R, Macey PM, Woo MA, Alger JR, Keens TG, Harper RM (2005) Neuroanatomic deficits in congenital central hypoventilation syndrome. J Comp Neurol 487: 361-371 Luo Z, McMullen NT, Costy-Bennett S, Fregosi RF (2007) Prenatal nicotine exposure alters glycinergic and GABAergic control of respiratory frequency in the neonatal rat brainstem-spinal cord preparation. Respir Physiol Neurobiol, in press Macey KE, Macey PM, Woo MA, Harper RK, Alger JR, Keens TG, Harper RM (2004) fMRI signal changes in response to forced expiratory loading in congenital central hypoventilation syndrome.
Respir Physiol 39: 217-239 Bradley CA, Fleetham JA, Anthonisen NR (1979) Ventilatory control in patients with hypoxemia due to obstructive lung disease. Am Rev Respir Dis 120: 21-30 Burtscher M, Flatz M, Faulhaber M (2004) Prediction of susceptibility to acute mountain sickness by SaO2 values during short-term exposure to hypoxia. High Alt Med Biol 5: 335-340 Byrne-Quinn E, Sodal IE, Weil JV (1972) Hypoxic and hypercapnic ventilatory drives in children native to high altitude. J Appl Physiol 32: 44-46 Byrne-Quinn E, Weil JV, Sodal IE, Filley GF, Grover RF (1971) Ventilatory control in the athlete.
A representative sample of Phox2-dependent ganglia and nuclei are schematized on a parasagittal section of a P0 mouse pup. The structures contained in the large triangle depend on both Phox2a and Phox2b, those below, only on Phox2b. The most rostral ones, enclosed in the small triangle, depend on Phox2a only. ens: enteric nervous system; g: ganglion; lc: locus cœruleus; nTS: nucleus of the solitary tract; pc: paracardiac ganglia; og: otic ganglion; sc: sympathetic chain; sm: submandibular ganglion; sp: sphenopalatine ganglion; VM/BM: column of branchial and visceral motoneurons.